{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:47:06Z","timestamp":1747187226754,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kidney transplantation is the preferred treatment for end\u2010stage renal failure. Unfortunately, donor organ shortages prevent many individuals receiving a renal transplant and there is a need to increase the pool of appropriate donors. The presence of acute kidney injury (AKI) in deceased donors has traditionally been a relative contraindication to renal transplantation, even though renal recovery may be favorable in the absence of chronic renal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook an 8\u2009years retrospective observational study of potential deceased organ donors with AKI requiring renal replacement therapy (RRT). We evaluated the rate of successful transplantation as well as short term and outcomes at a median of 19.5 (13.0\u201352.7) months after donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amongst 1058 consented potential organ donors, 39 patients had AKI requiring RRT, of which 19 became donors (13 not medically suitable, 7 did not proceed to donation). The median (interquartile range (IQR)) donor age was 41 (34\u201350) years and norepinephrine, epinephrine and vasopressin were given to 18, 14 and 9 donors, respectively. From the 38 donated kidneys 34 were transplanted. The median (IQR) age of recipients was 53 (42.8\u201358.5) years and they were dialysis free in a median (IQR) of 5.5 (2.3\u201310.8) days. Only minor abnormalities were found at 3 and 6\u2009months renal biopsies, and two patients experienced graft failure in the first 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Amongst deceased donors with AKI receiving RRT and vasoactive medications outcomes of renal transplantation seems acceptable in the absence of pre\u2010existing renal failure and other donor co\u2010morbidity. Such patients may be an important additional source of kidney donation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13601","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T07:19:30Z","timestamp":1557731970000},"page":"1296-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Frequency and outcomes of kidney donation from intensive care patients with acute renal failure requiring renal replacement therapy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6174-2751","authenticated-orcid":false,"given":"Jo M","family":"Sanders","sequence":"first","affiliation":[{"name":"DonateLife Victoria  Carlton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen I","family":"Opdam","sequence":"additional","affiliation":[{"name":"Austin Health  Heidelberg Victoria Australia"},{"name":"Organ and Tissue Authority Canberra  Canberra Canberra ACT Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Furniss","sequence":"additional","affiliation":[{"name":"DonateLife Victoria  Carlton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Nephrology Royal Melbourne Hospital, University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medicine (RMH) Royal Melbourne Hospital, University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kanellis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Health and Centre for Inflammatory Diseases Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine, Monash Health and Centre for Inflammatory Diseases Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl","family":"Jones","sequence":"additional","affiliation":[{"name":"Austin Health  Heidelberg Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Surgery University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"volume-title":"39th Report C. 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