{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:05:21Z","timestamp":1782439521721,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T00:00:00Z","timestamp":1563062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Joint Science and Technology Innovation Fund of Fujian province","award":["2016Y9001"],"award-info":[{"award-number":["2016Y9001"]}]},{"name":"Mrs. Rita T. Liu SBS of L & T Charitable Foundation Ltd & Indo Caf\u00e9, Mr. Winston Leung, and Mr. Chan Kwok Keung of the Hong Kong Concrete and Continental Cement and Gypsum Co. Ltd."},{"name":"Yu Professorship in Nephrology"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Increased arterial stiffness is associated with progressive renal deterioration and poor clinical outcomes in patients with chronic kidney disease (CKD). Assessment of vascular age as derived from arterial stiffness parameters might be an important clinical marker of cardiovascular risks. The aim of the present study is to evaluate whether the difference (\u25b3age) between vascular age and chronological age can predict the risk of reaching dialysis or death in patients with known CKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This longitudinal study enrolled 94 male Chinese CKD patients, aged 40\u201362\u2009years. Vascular age was calculated by brachial\u2010ankle pulse wave velocity, and measured by an ankle\u2010brachial index\u2010form device. The study endpoints were the commencement of renal replacement therapy or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a stepwise multivariate analysis, \u25b3age was associated independently with increased urine protein\u2010to\u2010creatinine ratio (<jats:italic>\u03b2<\/jats:italic> = 0.32; <jats:italic>P<\/jats:italic> = 0.001) and decreased baseline estimated glomerular filtration rate (<jats:italic>\u03b2<\/jats:italic> = \u22120.24; <jats:italic>P<\/jats:italic> = 0.008). During a median follow\u2010up period of 62 (interquartile range = 55\u201366) months, the 4\u2010year cumulative incidence of reaching the study endpoint in patients with \u25b3age = 0 and \u25b3age\u2009&gt;\u20090 year was 4.9% and 25%, respectively (log\u2013rank test, <jats:italic>P<\/jats:italic> = 0.009). Multivariate forward Cox regression analysis identified that higher \u25b3age (hazard ratio (HR) = 1.05; <jats:italic>P<\/jats:italic> = 0.027), lower baseline estimated glomerular filtration rate (HR = 0.93; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and history of cardiovascular disease (HR = 5.90; <jats:italic>P<\/jats:italic> = 0.031) were independently associated with progression to commencement of dialysis or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thus, the assessment of the difference between vascular age and chronological age may provide an alternative method to identify CKD patients at a high risk of progression to dialysis or death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13624","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T16:32:52Z","timestamp":1561134772000},"page":"314-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vascular age is associated with the risk of dialysis or death in chronic kidney disease"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4399-5856","authenticated-orcid":false,"given":"Miao","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Queen Mary Hospital The University of Hong Kong  Hong Kong"},{"name":"Division of Nephrology, Fujian Provincial Clinical College Fujian Medical University, Fujian Provincial Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary CW","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Queen Mary Hospital The University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam W","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Queen Mary Hospital The University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kar N","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Queen Mary Hospital The University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney CW","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Queen Mary Hospital The University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005101085"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07810910"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07700910"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000047"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.18.1837"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487313518479"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.037"},{"key":"e_1_2_7_10_1","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"Am. 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