{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:52:14Z","timestamp":1770749534026,"version":"3.50.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Monoclonal gammopathy of renal significance (MGRS)\u2010related lesions are infrequent entities. There are no publications on these disorders in Latin America (LA). The aim of this study was to describe epidemiological and clinical characteristics of these patients in LA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multicentre retrospective study. Patients with diagnosis of MGRS between 2012 and 2018 were included. Epidemiological and clinical data were collected from clinical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients from Chile, Argentina, Ecuador and Uruguay were included. Half debuted with a nephrotic syndrome, and 32% required dialysis. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits was found in 33%, amyloidosis in 26% and monoclonal immunoglobulin deposition disease also in 26%. The immunoglobulin most frequently found in renal biopsies was IgG kappa. In 67% a paraprotein was found. Twenty patients received an anti\u2010plasma cell regimen, and 3 a rituximab\u2010based regimen (IgM\u2010MGRS). Renal response (RR) was achieved in 56%. Early treatment (\u22643\u2009months) was associated with higher RR (75% vs 43%). Three patients relapsed within 21.5 months, and 3 progressed: 1 to multiple myeloma, 1 to systemic amyloidosis and another to systemic light\u2010chain deposition disease. Two patients died, both due to infection during induction treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a higher than expected frequency of patients requiring dialysis. The most common MGRS\u2010related lesion was PGNMD. Early treatment was associated with better response. As a rare disease, increasing awareness and promoting early diagnosis are necessary in LA to improve outcomes.<\/jats:p><jats:p><jats:boxed-text content-type=\"box\" position=\"float\"><jats:caption><jats:title>SUMMARY AT A GLANCE<\/jats:title><\/jats:caption><jats:p>A collection of 27 cases of MGRS from Latin America with information on epidemiology, clinical characteristics, treatment and outcome of patients diagnosed of MGRS\u2010related renal lesions.<\/jats:p><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13685","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T15:51:09Z","timestamp":1576079469000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epidemiological and clinical characteristics and outcome of monoclonal gammopathy of renal significance\u2010related lesions in Latin America"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-2077","authenticated-orcid":false,"given":"Camila","family":"Pe\u00f1a","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital del Salvador  Santiago de Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia P.","family":"Schutz","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elo\u00edsa","family":"Riva","sequence":"additional","affiliation":[{"name":"Department of Hematology C\u00e1tedra de Hematolog\u00eda, Hospital de Cl\u00ednicas, Facultad de Medicina  Montevideo Uruguay"},{"name":"Department of Hematology Hospital Brit\u00e1nico  Montevideo 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Hematology FUSAT  Rancagua Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Verri","sequence":"additional","affiliation":[{"name":"Department of Hematology Instituto de Investigaciones M\u00e9dicas Alfredo Lanari \u2013 UBA  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Rojas","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Gustavo Fricke  Vi\u00f1a del Mar Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Escobar","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Gustavo Fricke  Vi\u00f1a del Mar Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Glavic","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital S\u00f3tero del R\u00edo  Santiago de 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