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cells. Both sUMOD and uUMOD are correlated with estimated glomerular filtration rate (eGFR), and associated with mortality and cardiovascular disease (CVD). However, no study to our knowledge has measured both sUMOD and uUMOD in the same population, thus the relationship of sUMOD with uUMOD with one another, and their respective correlates have not been evaluated simultaneously. We evaluated the correlations of sUMOD, uUMOD with eGFR in a random sub\u2010cohort (n = 933) of the Cardiovascular Health Study and their associations with demographic and laboratory parameters and CVD risk factors using multi\u2010variable linear regression analysis. The mean age of the cohort was 78\u2009years, 40% were male and 15% were Black. The mean sUMOD level was 127\u2009ng\/mL, uUMOD was 30\u2009500\u2009ng\/mL and eGFR was 63\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    . Correlation between sUMOD and uUMOD, adjusted for eGFR was moderate (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.27 [95% confidence interval = 0.21\u20100.33]). The correlation of eGFR with sUMOD (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.44 [0.39\u20100.49]) was stronger than with uUMOD (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.21 [0.15\u20100.27]). In multi\u2010variable analysis adjusting sUMOD for uUMOD and vice versa, sUMOD was independently associated with eGFR (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = 1.3 [1.1\u20101.6]), log2 C\u2010reactive protein (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = \u22124.2 [\u22126.8 to \u22121.6]) and male sex (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = \u221213.6 [\u221222.7 to \u22124.5]). In contrast, male sex was associated with higher uUMOD (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = 3700 [400\u20107000]), while diabetes (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    = \u22126400 [\u221210 600 to \u22122100]) and hypertension (\u22124300 [\u22127500 to \u22121100]) were associated with lower uUMOD levels. We conclude that sUMOD is more strongly associated with eGFR compared with uUMOD. Correlates of sUMOD and uUMOD differ substantially, suggesting that apical and basolateral secretion may be differentially regulated.\n                  <\/jats:p>","DOI":"10.1111\/nep.13688","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T11:21:00Z","timestamp":1576581660000},"page":"522-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Association of serum and urinary uromodulin and their correlates in older adults\u2014The Cardiovascular Health Study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-8560","authenticated-orcid":false,"given":"Dominik","family":"Steubl","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Tufts Medical Center  Boston Massachusetts"},{"name":"Division of Nephrology Klinikum rechts der Isar, Technical University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Buzkova","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[{"name":"Division of Nephrology\u2010Hypertension University of California San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Devarajan","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Cincinnati Children's Hospital, University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Cincinnati Children's Hospital, University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo H. M.","family":"Chaves","sequence":"additional","affiliation":[{"name":"Benjamin Leon Center for Geriatric Research and Education Herbert Wertheim College of Medicine, Florida International University  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine University of California San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Bansal","sequence":"additional","affiliation":[{"name":"Division of Nephrology Kidney Research Institute, University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Sarnak","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Tufts Medical Center  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav S.","family":"Garimella","sequence":"additional","affiliation":[{"name":"Division of Nephrology\u2010Hypertension University of California San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.101"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00083.2008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00543.2012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.192"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.02.024"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-9-201005040-00006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014070696"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw422"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016111162"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw3639"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03600318"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(92)90351-P"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160978"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft345"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.13688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.13688","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T08:45:46Z","timestamp":1693989946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,27]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/nep.13688"],"URL":"https:\/\/doi.org\/10.1111\/nep.13688","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,27]]},"assertion":[{"value":"2019-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}