{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:26:29Z","timestamp":1782278789232,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/7\u20105\/14\/NCD\u2010II"],"award-info":[{"award-number":["5\/4\/7\u20105\/14\/NCD\u2010II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Rituximab is currently used after the conventional agents have failed in the management of steroid\u2010dependent (SD)\/ steroid\u2010resistant (SR) podocytopathies and have a safer toxicity profile. We report 53 adults with podocytopathies who were managed effectively with CD19\u2010targeted rituximab therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study carried out at a tertiary care centre in India between January 2014 and June 2019. Adults between 16 and 60\u2009years with SD, frequently relapsing (FR), and SR nephrotic syndrome (NS) due to podocytopathy received rituximab in a CD19\u2010targeted approach. Primary outcome: Percentage of patients who were in remission at 6 and 12\u2009months. Secondary outcome: Percentage of patients in remission at the last follow\u2010up, rituximab dose and adverse events of rituximab therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three adults with SD\/FR\/SR NS received CD19\u2010targeted rituximab. The median age at the time of first rituximab injection was 30.09\u2009\u00b1\u200913.21 (16.53) years. At the time of first rituximab infusion, all patients were in remission with steroids and\/or calcineurin inhibitors (CNIs). Fifty (94.33%) patients were in remission at the end of 6 and 12\u2009months and the last follow\u2010up (median: 36\u2009months). The mean total dose of rituximab at 1 year was 788.7 \u00b1\u2009128.1 (6\u2009001\u2009100) mg. At last follow\u2010up (median 36\u2009months), 42 (79%) patients did not require any additional CNI or steroids therapy. No serious adverse events to rituximab were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CD19\u2010targeted rituximab therapy is safe and efficacious in the management of SD\/SR adult podocytopathy. Also, rituximab is effective in maintaining remission in treatment na\u00efve adult SD or FR podocytopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13717","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T08:55:10Z","timestamp":1587027310000},"page":"616-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Rituximab in maintaining remission in adults with podocytopathy"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-9107","authenticated-orcid":false,"given":"Raja","family":"Ramachandran","sequence":"first","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyita","family":"Bharati","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education 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