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Less than 6% of patients in the Australia and global cohorts were reported to have a history of autoimmune disease (4% vs 2%, respectively; <jats:italic>P<\/jats:italic> =\u2009.21) or cancer (5% vs 5%, respectively; <jats:italic>P<\/jats:italic> =\u2009.93), conditions that have been associated with secondary HUS. In the Australian cohort, 26% had received a kidney transplant and 68% of patients had received eculizumab. Kidneys were the most common organ involvement, followed by gastrointestinal tract (26%) and cardiovascular system (19%), with 35% of patients reported to have had at least two organs involved within 6 months prior to baseline visit or entry into the registry. Complement factor H was the most common pathogenic complement gene variant in the Australian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data from the aHUS registry confirms and defines region\u2010specific disease characteristics among a selected group of Australian children and adults with aHUS reported to the registry. Ongoing and more inclusive data will provide further information about temporal trends and treatment outcomes, representing a unique opportunity for clinicians and researchers to further develop knowledge surrounding this rare disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13722","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T07:39:54Z","timestamp":1588837194000},"page":"683-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Baseline characteristics of patients with atypical haemolytic uraemic syndrome (<scp>aHUS<\/scp>): The Australian cohort in a global <scp>aHUS<\/scp> registry"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-0691","authenticated-orcid":false,"given":"Jacqueline","family":"Soraru","sequence":"first","affiliation":[{"name":"Department of Renal Medicine Sir Charles Gairdner Hospital  Perth Western Australia 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