{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:34:33Z","timestamp":1782902073389,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical use of continuous bumetanide infusion for acute heart failure and volume overload is common. However, there is not enough supporting evidence for the use of continuous bumetanide infusion. Thus, we conducted this systematic review and meta\u2010analysis aiming to describe the treatment outcomes of continuous bumetanide infusion. We searched Ovid MEDLINE, EMBASE and the Cochrane Library for eligible publications. Inclusion criteria were patients age \u226518\u2009years with bumetanide infusion for heart failure, acute kidney injury (AKI) or volume overload. From 1564 citations, three studies (n = 94 patients) were included in the systematic review and meta\u2010analysis. The mean dose of bumetanide was 1.08\u2009\u00b1\u20090.43\u2009mg\/hour with a mean treatment duration of 45.09 \u00b1 10.12\u2009hours. Mean urine output in response to continuous bumetanide infusion was 1.88\u2009mL\/kg\/hour (95% confidence interval [CI], 1.72\u20102.05). The incidence of AKI with continuous bumetanide infusion was 24.7% (95% CI, 8.2\u201054.6). By using Pearson's correlation coefficient, increasing doses of bumetanide were correlated with increased urine output (<jats:italic>P<\/jats:italic> = .026) and increased incidence of AKI (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). There was no correlation between increasing urine output and the incidence of AKI (<jats:italic>P<\/jats:italic> = .739). In conclusion, with available evidence, continuous bumetanide infusion may be used in the treatment of acute heart failure or volume overload with close monitoring for new\u2010onset or worsening AKI.<\/jats:p>","DOI":"10.1111\/nep.13739","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:38:21Z","timestamp":1595983101000},"page":"744-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment outcomes of bumetanide continuous infusion: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5041-4290","authenticated-orcid":false,"given":"Panupong","family":"Hansrivijit","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Pittsburgh Medical Center Pinnacle  Harrisburg Pennsylvania 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Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wisit","family":"Cheungpasitporn","sequence":"additional","affiliation":[{"name":"Division of Nephrology University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2014.03.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199712000-00011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14038"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09771-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-0539-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.153"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000425149.79348.49"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1886-36552013000100008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248413482755"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.13739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.13739","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T20:12:13Z","timestamp":1693944733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,28]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/nep.13739"],"URL":"https:\/\/doi.org\/10.1111\/nep.13739","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,28]]},"assertion":[{"value":"2020-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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