{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:28:10Z","timestamp":1783067290785,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Collapsing focal segmental glomerulosclerosis (cFSGS) is an aggressive glomerular disease presenting as a nephrotic syndrome that has lower rates of remission with conventional immunosuppressive therapy and rapidly progresses to end\u2010stage\u2010renal\u2010disease (ESRD). We report eight cases of HIV\u2010negative cFSGS treated with rituximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current report is a retrospective case series of cFSGS treated with rituximab from January 2011 to March 2020, at varying phases of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight out of the 70 cFSGS patients received rituximab. The median age of patients was 30\u2009years (IQR 24.25\u201037.5); five patients were males. The median serum creatinine, mean serum albumin and median 24\u2009hours urinary protein at presentation was 0.9 (IQR 0.66\u20101.27) mg\/dL, 2.95\u2009\u00b1\u20091.15\u2009g\/dL, 4.87 (IQR 1.64\u20105.75) g\/day, respectively. Two patients were steroid\u2010resistant, one steroid and tacrolimus dependent, one steroid and cyclosporine dependent, two steroids and tacrolimus resistant, one steroid, tacrolimus, cyclophosphamide, mycophenolate mofetil resistant and one steroid\u2010resistant and tacrolimus dependent before rituximab therapy. Rituximab was given either as targeted therapy (after an initial dose of 375\u2009mg\/m<jats:sup>2<\/jats:sup>; patients having CD\u201019 levels &gt;5\/\u03bcL or &gt;1% at 1\u2009month received additional low\u2010dose [100\u2009mg] of rituximab), or weekly regimen. Five patients received CD\u201019 targeted rituximab; three received weekly doses of 375\u2009mg\/m<jats:sup>2<\/jats:sup>, cumulative doses being 820\u2009\u00b1\u2009228.03\u2009mg, and 1800 \u00b1 721.11 mg, respectively. At the end of median follow\u2010up of 15\u2009months, five (62.5%) patients were in remission (three partial, two complete remissions), two (25%) were resistant to therapy; one (12.5%) progressed to ESRD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rituximab is reasonably safe and achieves\/maintains remission in 60% of cFSGS cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13757","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T10:48:38Z","timestamp":1594723718000},"page":"134-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rituximab in treatment of collapsing <scp>FSGS<\/scp>\u2014A case series"],"prefix":"10.1111","volume":"26","author":[{"given":"Niveditha","family":"Girimaji","sequence":"first","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyita","family":"Bharati","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritambhra","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-2297","authenticated-orcid":false,"given":"Harbir Singh","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-9107","authenticated-orcid":false,"given":"Raja","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030225"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.493"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000160"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2016.1164063"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050028"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-008-0053-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00769.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13091215"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.444"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360908"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13717"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00570109"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20858"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00950.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002231"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0781-6"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1410-8"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sft102"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.02.063"},{"key":"e_1_2_5_21_1","first-page":"139","article-title":"Improving global outcomes (KDIGO) glomerulonephritis work group. 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