{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:07:48Z","timestamp":1784005668611,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Chronic heart failure may lead to chronic kidney disease. Previous studies suggest tubular markers N\u2010acetyl\u2010b\u2010D\u2010glucosaminidase (NAG) and Kidney\u2010injury\u2010molecule\u20101 (KIM\u20101) as potential markers for the cardiorenal syndrome (CRS). The prognostic value of NAG and KIM\u20101 regarding implantable cardioverter defibrillator (ICD) shock therapies is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 314 patients with an ICD and collected plasma and urine samples. Urine\u2010values of NAG and KIM\u20101 got related to urinary creatinine. Outcomes of interest were sustained adequate shock therapies and a combined endpoint of all\u2010cause mortality, rehospitalisation due to congestive heart failure and adequate shock therapies. Follow up time was 32\u2009months (IQR 6\u201035\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>KIM\u20101 and NAG were positively correlated with NT\u2010proBNP (KIM\u20101: <jats:italic>r<\/jats:italic> = .34, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001; NAG: <jats:italic>r<\/jats:italic> = .47, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). NAG was significantly elevated in patients with primary prevention compared with secondary prevention ICD indication (<jats:italic>P<\/jats:italic> = .003). According to Kaplan Meier analysis, NAG as well as NT\u2010proBNP were significant predictors for adequate ICD shock therapies and for the combined endpoint (each <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Elevated KIM\u20101 showed no significant differences (each <jats:italic>P<\/jats:italic> = n.s.). In multivariate cox regression analysis, NAG as well as NT\u2010proBNP were both independent predictors for adequate ICD shock therapies as well as the combined endpoint, beside ejection fraction &lt;35% (each <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Diabetes, primary prevention ICD indication, coronary artery disease, eGFR and age were no significant predictors for both endpoints (each <jats:italic>P<\/jats:italic> = n.s.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Similar to NT\u2010proBNP, NAG showed promising value for overall prognostication in ICD patients. Especially, NAG seems to incorporate an additional prognostic value regarding occurrence of ICD shock therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13776","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T07:08:46Z","timestamp":1598425726000},"page":"888-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>N\u2010acetyl\u2010b\u2010D<\/scp>\u2010glucosaminidase: A potential cardiorenal biomarker with a relevant impact on <scp>ICD<\/scp> shock therapies and mortality"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-447X","authenticated-orcid":false,"given":"Raphael","family":"Allgaier","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Strack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wallner","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Hubauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekrem","family":"Uecer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Lehn","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Keyser","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Medical Center Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Luchner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Barmherzige Br\u00fcder Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Medical Center Regensburg  Regensburg 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