{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:55:05Z","timestamp":1770843305278,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present study aimed to investigate the value of calcium\u2010mediated parathyroid hormone (PTH) suppression test in evaluating the autonomic secretory function of parathyroid, and the management of uraemic secondary hyperparathyroidism (SHPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Calcium\u2010mediated PTH suppression test was performed in dialysis with SHPT, who were candidates for parathyroidectomy from June 2017 to December 2019 in our hospital. The PTH inhibition rate (PTH\u2010IR) was calculated, and the correlation between PTH\u2010IR and clinical indicators was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one subjects were included. PTH\u2010IR was negatively correlated with baseline PTH (<jats:italic>r<\/jats:italic> = \u22120.35, <jats:italic>P<\/jats:italic> = .012), it was also correlated with dialysis years, coronary artery calcification score (CACS) and parathyroid mass (<jats:italic>r<\/jats:italic> = \u22120.397, <jats:italic>P<\/jats:italic> = .004; <jats:italic>r<\/jats:italic> = \u22120.327, <jats:italic>P<\/jats:italic> = .028; <jats:italic>r<\/jats:italic> = \u22120.363, <jats:italic>P<\/jats:italic> = .015), which were not found for baseline PTH. Forty\u2010four patients underwent surgical treatment. According to the histological results, 26 patients presented with parathyroid non\u2010nodular hyperplasia, and 18 patients presented with parathyroid nodular hyperplasia. The mass of parathyroid of patients with nodular hyperplasia was higher than that of patients with non\u2010nodular hyperplasia (<jats:italic>\u03c1<\/jats:italic> = 0.01). The difference of the PTH\u2010IR was not found between the two groups (<jats:italic>\u03c1<\/jats:italic> = 0.296). During the test, the highest serum calcium was 2.9\u2009\u00b1\u20090.4\u2009mmol\/L, which dropped to normal at the end of the test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parathyroid hormone inhibition rate might be a useful indicator in evaluating the autonomic secretory function of parathyroid and the progression of SHPT on top of intact PTH. Calcium\u2010mediated PTH suppression test was safe in uraemic SHPT patients, but need to monitor for transient hypercalcaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13807","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T13:07:21Z","timestamp":1602767241000},"page":"164-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Calcium\u2010mediated <scp>parathyroid hormone<\/scp> suppression test in uraemic secondary hyperparathyroidism"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8130-6068","authenticated-orcid":false,"given":"Ting","family":"Xiang","sequence":"first","affiliation":[{"name":"Division of Nephrology Kidney Research Institute, West China Hospital of Sichuan University  Chengdu 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