{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:51:27Z","timestamp":1773139887621,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the epidemiology and clinical outcomes of catheter\u2010related infections of <jats:italic>Serratia<\/jats:italic> species in peritoneal dialysis (PD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the patient characteristics, antibiotics susceptibility\/resistance patterns and treatment outcomes of exit site infection (ESI) and peritonitis due to <jats:italic>Serratia<\/jats:italic> in PD patients during the period of 2004 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixty\u2010one patients had <jats:italic>Serratia<\/jats:italic> ESI, of which 10 (6.2%) progressed to tunnel tract involvement and 11 (6.8%) developed PD peritonitis. Nineteen (11.8%) patients with <jats:italic>Serratia<\/jats:italic> ESI failed to respond to medical treatment and required catheter removal. Fifty\u2010six (34.8%) patients had repeat <jats:italic>Serratia<\/jats:italic> ESI, which occurred at 12.9\u2009\u00b1\u200913.6 months after the previous episode. Twenty\u2010two patients had <jats:italic>Serratia<\/jats:italic> peritonitis, which accounted for 1% of peritonitis during the study period. Ten (45.5%) patients responded to medical treatment while 12 (54.5%) patients required catheter removal. Nine patients (36.4%) failed to resume PD and were converted to long\u2010term haemodialysis. Two patients had repeat peritonitis at 2 months and 3\u2009years, respectively, after the initial episode. <jats:italic>Serratia<\/jats:italic> species in PD patients showed high rates of resistance to ampicillin, and first\u2010 and second\u2010generation cephalosporins, but were generally susceptible to aminoglycosides, carboxy\u2010\/ureido\u2010penicillins and carbapenems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that <jats:italic>Serratia<\/jats:italic> ESI show low risk of progression to peritonitis and favourable response to medical therapy, while <jats:italic>Serratia<\/jats:italic> peritonitis was associated with high rates of catheter removal and peritoneal failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13813","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T07:54:44Z","timestamp":1604562884000},"page":"255-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exit site infection and peritonitis due to <i>Serratia<\/i> species in patients receiving peritoneal dialysis: Epidemiology and clinical outcomes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9851-2482","authenticated-orcid":false,"given":"Christy W. H.","family":"Au","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Queen Mary Hospital, The University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8179-8293","authenticated-orcid":false,"given":"Desmond Y. H.","family":"Yap","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Queen Mary Hospital, The University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper F. W.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Microbiology Queen Mary Hospital, The University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence P. S.","family":"Yip","sequence":"additional","affiliation":[{"name":"Renal Unit Tung Wah Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak M.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Queen Mary Hospital, The University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-10-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.08.046"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00980112"},{"issue":"10","key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1681\/ASN.V7102176","article-title":"Peritonitis influences mortality in peritoneal dialysis patients","volume":"7","author":"Fried LF","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080302300509"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP75416"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.149"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000037"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196499"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00017-11"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01083-07"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.1.105"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5449.1536"},{"issue":"2","key":"e_1_2_5_15_1","first-page":"64","article-title":"Serratia marcescens peritonitis in a patient receiving chronic ambulatory peritoneal dialysis complicated by osteomyelitis","volume":"147","author":"Bizette GA","year":"1995","journal-title":"J La State Med Soc"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.15.4.728-730.1982"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01716283"},{"key":"e_1_2_5_18_1","first-page":"202","article-title":"An outbreak of Serratia marcescens infection among obstetric patients","volume":"97","author":"Stephen M","year":"1993","journal-title":"Indian J Med Res"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(91)90093-N"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(02)00163-2"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg156"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080202200508"},{"key":"e_1_2_5_23_1","first-page":"73","article-title":"Technique survival with Serratia peritonitis","volume":"22","author":"Hiremath S","year":"2006","journal-title":"Adv Perit Dial"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.13813","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T13:38:32Z","timestamp":1693661912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,2]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/nep.13813"],"URL":"https:\/\/doi.org\/10.1111\/nep.13813","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,2]]},"assertion":[{"value":"2020-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}