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Large cardiovascular outcome trials and dedicated kidney trials have shown that sodium\u2010glucose cotransporter (SGLT)2 inhibitors reduce cardiovascular morbidity and mortality and attenuate hard renal outcomes in patients with type 2 diabetes (T2D). Underlying mechanisms explaining these renal benefits may be mediated by decreased glomerular hypertension, possibly by vasodilation of the post\u2010glomerular arteriole. People with T2D often receive several different drugs, some of which could also impact the renal vasculature, and could therefore modify both renal efficacy and safety of SGLT2 inhibition. The most commonly prescribed drugs that could interact with SGLT2 inhibitors on renal haemodynamic function include renin\u2010angiotensin system inhibitors, calcium channel blockers and diuretics. Herein, we review the effects of these drugs on renal haemodynamic function in people with T2D and focus on studies that measured glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) with gold\u2010standard techniques. In addition, we posit, based on these observations, potential interactions with SGLT2 inhibitors with an emphasis on efficacy and safety.<\/jats:p>","DOI":"10.1111\/nep.13839","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T02:29:23Z","timestamp":1607308163000},"page":"377-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Renal haemodynamic and protective effects of renoactive drugs in type 2 diabetes: Interaction with SGLT2 inhibitors"],"prefix":"10.1111","volume":"26","author":[{"given":"Rosalie A.","family":"Scholtes","sequence":"first","affiliation":[{"name":"Amsterdam Diabetes Center, Department of Internal Medicine, Academic Medical Center VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl J. 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