{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:55:41Z","timestamp":1784674541548,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","award":["Jacquot Research Establishment"],"award-info":[{"award-number":["Jacquot Research Establishment"]}],"id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are few studies that have examined whether dysbiosis occurs in kidney donors and transplant recipients following kidney transplant surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To ascertain whether changes occur in the gastrointestinal microbiota of the kidney donor and recipient following kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Kidney transplant recipients and their donors were prospectively enrolled in a pilot study to collect one faecal sample prior to, and another faecal sample between four to eight weeks following surgery. Gastrointestinal microbiota richness, Shannon diversity measures and functional assessments of kidney donors and recipients were analysed via metagenomic sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 12 donors (median age 56 years, 6 females) and 12 recipients (median age 51 years, 3 females). Donor microbiota showed no significant changes in gastrointestinal microbiota richness, Shannon diversity, or functional assessments before and after nephrectomy. Recipient microbiota was altered post\u2010transplant, reflected in reductions of the mean (\u00b1SD) richness values (156 \u00b1 46.5 to 116 \u00b1 38.6, p = 0.002), and Shannon diversity (3.57 \u00b1 0.49 to 3.14 \u00b1 0.52, p = 0.007), and a dramatic increase in Roseburia spp. abundance post\u2010transplant (26\u2010fold increase from 0.16 \u00b1 0.0091 to 4.6 \u00b1 0.3; p = 0.006; FDR = 0.12). Functionally, the post\u2010transplant microbial community shifted towards those taxa using the glycolysis pathway (1.2\u2010fold increase; p = 0.02; FDR = 0.26) for energy metabolism, while those functions involved with reactive oxygen species degradation decreased (2.6\u2010fold; p = 0.006; FDR = 0.14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Live donor kidney transplantation and standard care post\u2010transplant result in significant alterations in gut microbiota richness, diversity, composition and functional parameters in kidney transplant recipients but not in their kidney donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13853","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T03:59:20Z","timestamp":1611719960000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characteristics of the gastrointestinal microbiota in paired live kidney donors and recipients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8321-4447","authenticated-orcid":false,"given":"Samuel","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Australasian Kidney Trials Network The University of Queensland  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Morrison","sequence":"additional","affiliation":[{"name":"The University of Queensland Diamantina Institute, Faculty of Medicine University of Queensland  Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel M.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital  Brisbane Queensland 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M.","family":"Isbel","sequence":"additional","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Australasian Kidney Trials Network The University of Queensland  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M.","family":"Pascoe","sequence":"additional","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Nephrology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Australasian Kidney Trials Network The University of Queensland  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland 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