{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:08:54Z","timestamp":1770905334459,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to determine the frequency of COVID\u201019 related AKI and to identify the early predictors of AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a single\u2010center, retrospective, observational study. Hospitalized COVID\u201019 patients between 24\/03\/2020 and 31\/05\/2020 were included in the study. All patients were evaluated for renal dysfunctions with urine dipstick, protein\/creatinine ratio, albumin\/creatinine ratio in spot urine, serum cystatin C, serum creatinine level on hospital admission, and 28th day of hospital admission. To assess the utility of these parameters to predict AKI, a receiver\u2010operating characteristic curve was generated and the area under the curve (AUC) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>348 patients were included. The average incidence of AKI was 4.9% (n = 17). The incidence of AKI in mild, moderate and severe COVID\u201019 cases was 1.3% (n = 4), 9.0% (n = 3) and 76.9% (n = 10), respectively. Proteinuria was detected in 7.8% (n = 27) of patients with a urine dipstick test. In spot urine analysis, proteinuria was found in 20.1% (n = 70) of patients. The frequency of persistent proteinuria was 5.2% (n = 18). The AUC alue of serum cystatin C, D\u2010dimer and albumin\/creatinine ratio to predict COVID\u201019 related AKI were 0.96 (0.90 to 1.0), 0.94 (0.89\u20130.98), and 0.95 (0.91\u20130.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In COVID\u201019 patients with normal serum creatinine levels on hospital admission, albuminuria, serum cystatin C and D\u2010dimer levels may be an early predictor of COVID\u201019 related AKI and these patients should be monitored closely for AKI. Since the sample size in the AKI group was small, our study results should be confirmed with larger cohort studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13856","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T14:44:07Z","timestamp":1611758647000},"page":"513-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Early predictors of acute kidney injury in <scp>COVID<\/scp>\u201019 patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Cigdem","family":"Yildirim","sequence":"first","affiliation":[{"name":"Infectious Disease and Clinical Microbiology Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-0092","authenticated-orcid":false,"given":"Hasan Selcuk","family":"Ozger","sequence":"additional","affiliation":[{"name":"Infectious Disease and Clinical Microbiology Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Yasar","sequence":"additional","affiliation":[{"name":"Nephrology Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazrin","family":"Tombul","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Gulbahar","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Infectious Disease and Clinical Microbiology Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulendam","family":"Bozdayi","sequence":"additional","affiliation":[{"name":"Medical Microbiology Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulver","family":"Derici","sequence":"additional","affiliation":[{"name":"Nephrology Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Dizbay","sequence":"additional","affiliation":[{"name":"Infectious Disease and Clinical Microbiology Department Gazi University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO.Coronavirus disease (COVID\u201019) weekly epidemiological update.https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200914-weekly-epi-update. 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