{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:08Z","timestamp":1747187108148,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Worsening renal function (WRF) induced by acute myocardial infarction (AMI) is a strong predictor of cardiovascular events and mortality. Peak oxygen uptake may contribute to prognosis in AMI patients with WRF, however, the impact of WRF on peak oxygen uptake is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 154 patients with AMI who underwent emergency percutaneous coronary intervention and participated in phase II cardiac rehabilitation, those who underwent cardiopulmonary exercise testing were consecutively enrolled. WRF was defined as a \u226520% decrease in estimated glomerular filtration rate (eGFR [ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>]) from admission to that at cardiopulmonary exercise testing. The association of WRF with peak oxygen uptake was evaluated by multivariate regression analysis. The non\u2010WRF group was divided into two subgroups according to eGFR &lt;60\/\u226560 at cardiopulmonary exercise testing, and eGFR at cardiopulmonary exercise testing and peak oxygen uptake of all three groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010four patients were enrolled in the final analysis. Multiple linear regression analysis showed that WRF was associated with peak oxygen uptake (<jats:italic>p<\/jats:italic> =\u2009.003). Comparing the non\u2010WRF group with eGFR at cardiopulmonary exercise testing &lt;60 and the WRF group, although eGFR at cardiopulmonary exercise testing was similar (<jats:italic>p<\/jats:italic> =\u20091.000), peak oxygen uptake in the WRF group was significantly lower (<jats:italic>p<\/jats:italic> =\u2009.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WRF, not eGFR at cardiopulmonary exercise testing was significantly associated with peak oxygen uptake in patients with AMI. This result suggests that when considering the relationship between renal function and peak oxygen uptake, WRF must be taken into account.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13864","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T08:23:43Z","timestamp":1613723023000},"page":"506-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of worsening renal function on peak oxygen uptake in patients with acute myocardial infarction"],"prefix":"10.1111","volume":"26","author":[{"given":"Asami","family":"Ogura","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sanda City Hospital  Sanda Japan"},{"name":"Department of Public Health, Graduate School of Health Sciences Kobe University  Kobe Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP)  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-8903","authenticated-orcid":false,"given":"Kazuhiro P.","family":"Izawa","sequence":"additional","affiliation":[{"name":"Department of Public Health, Graduate School of Health Sciences Kobe University  Kobe Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP)  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Tawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sanda City Hospital  Sanda Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumie","family":"Kureha","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sanda City Hospital  Sanda Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sanda City Hospital  Sanda Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Public Health, Graduate School of Health Sciences Kobe University  Kobe Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP)  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Public Health, Graduate School of Health Sciences Kobe University  Kobe Japan"},{"name":"Cardiovascular Stroke Renal Project (CRP)  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sanda City Hospital  Sanda Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sanda City Hospital  Sanda Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.167.2.211"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.184461"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw303"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0806"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0779"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.02.033"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.02.019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2014.12.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319716646680"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-011-0177-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2017.11.015"},{"volume-title":"ACNS's Guidelines for Exercise Testing and Prescription","year":"2014","author":"Pescatello LS","key":"e_1_2_7_13_1"},{"key":"e_1_2_7_14_1","first-page":"1514","article-title":"Japanese standard value of respirocirculatory index on exercise","volume":"56","author":"Murayama M","year":"1992","journal-title":"Jpn Circ J"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181e52e69"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.940577"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.44.187"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201612-997FR"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(99)00003-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.11.053"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12827"},{"key":"e_1_2_7_24_1","first-page":"12","article-title":"Beta\u2010adrenergic pathways in nonfailing and failing human ventricular myocardium","volume":"82","author":"Bristow MR","year":"1990","journal-title":"Circulation"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.2.314"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00301"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02162-9"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp188"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.12.087"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0556-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0542"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.07.019"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP74245"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000664"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318789225"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.2_Suppl.S36"},{"volume-title":"Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications","year":"2011","author":"Wasserman K","key":"e_1_2_7_37_1"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.17795\/mejrh-24168"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.076844"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.10.015"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.13864","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T04:17:00Z","timestamp":1693541820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,2]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/nep.13864"],"URL":"https:\/\/doi.org\/10.1111\/nep.13864","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"type":"print","value":"1320-5358"},{"type":"electronic","value":"1440-1797"}],"subject":[],"published":{"date-parts":[[2021,3,2]]},"assertion":[{"value":"2020-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}