{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:24:05Z","timestamp":1751005445153,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Early graft loss is a devastating kidney transplant complication associated with high mortality and an increased risk of sensitization to antigens from the failed graft. Moreover, if rapid re\u2010transplantation were to occur, given that the human leukocyte antigen antibodies identification may not be reliable until several weeks after transplantation, the recipient's immunological status would be uncertain. Hence, there could be an increased immunological risk. To date, there is no information on whether a rapid re\u2010transplantation after early graft loss, without a new reliable anti\u2010HLA determination, is safe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed the number of rejections and the graft survival of re\u2010transplanted patients with early graft loss (defined as graft failure before 30\u2009days from transplant) from our centre between June 2003 and November 2019. The studied population was divided into rapid re\u2010transplantation (performed within 30\u2009days of early graft loss) and late re\u2010transplantation (performed beyond those 30\u2009days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven patients were re\u2010transplanted after early graft loss. There were nine rapid re\u2010transplantation cases with an 89% five\u2010year graft survival and one antibody\u2010mediated rejection episode. Furthermore, we identified 38 cases of late re\u2010transplantation with a 69% five\u2010year graft survival, 4 T cell\u2010mediated, and 11 antibody\u2010mediated rejections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rapid re\u2010transplantation appears to be safe and does not entail increased rejection risk, nor does it impact long\u2010term graft survival when compared to late re\u2010transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13907","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T18:20:40Z","timestamp":1622312440000},"page":"742-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rapid re\u2010transplantation safety following early kidney graft loss"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-7156","authenticated-orcid":false,"given":"Diana","family":"Rodr\u00edguez\u2010Espinosa","sequence":"first","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Hospital Cl\u00ednic of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-9083","authenticated-orcid":false,"given":"Jos\u00e9 Jes\u00fas","family":"Broseta","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Hospital Cl\u00ednic of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Hermida","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Hospital Cl\u00ednic of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Cuadrado","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Hospital Cl\u00ednic of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Guill\u00e9n\u2010Olmos","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Hospital Cl\u00ednic of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Montagud\u2010Marrahi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Hospital Cl\u00ednic of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fritz","family":"Diekmann","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation Hospital Cl\u00ednic of Barcelona  Barcelona Spain"},{"name":"Laboratori Experimental de Nefrologia i Trasplantament (LENIT) Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Red de Investigaci\u00f3n Renal (REDINREN)  Madrid 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