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While angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) are, without a doubt, safe and effective drugs, a significant proportion of patients with CKD still progress to end\u2010stage kidney disease. After decades of negative trials, nephrologists have finally found cause for optimism with the introduction of sodium\u2010glucose cotransporter\u20102 (SGLT2) inhibitors and non\u2010steroidal mineralocorticoid receptor antagonists (MRAs). Recent trials such as EMPA\u2010REG OUTCOME and CREDENCE have provided evidence of the renal benefits of SGLT2 inhibitors, which have now found widespread acceptance as first\u2010line agents for diabetic CKD, in addition to ACEi\/ARBs. Considering results from the DAPA\u2010CKD study, it is expected that their use will soon be expanded to other causes of albuminuric CKD as well, although confirmation from further trials, such as the EMPA\u2010KIDNEY study is awaited. Likewise, although the role of mineralocorticoid receptor overactivation in CKD progression has been known for decades, it is only now with the FIDELIO\u2010DKD study that we have evidence of benefits of MRAs on hard renal endpoints, specifically in patients with diabetic CKD. While further research is ongoing, given the evidence of synergism between the three drug classes, it is foreseeable that a combination of two or more of these drugs may soon become the standard of care for CKD, regardless of underlying aetiology. This review describes pathophysiologic mechanisms, current evidence and future perspectives on the use of SGLT2 inhibitors and novel MRAs in CKD.<\/jats:p>","DOI":"10.1111\/nep.13917","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T10:06:17Z","timestamp":1624788377000},"page":"858-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sodium\u2010glucose cotransporter\u20102 inhibitors and non\u2010steroidal mineralocorticoid receptor antagonists: Ushering in a new era of nephroprotection beyond renin\u2010angiotensin system blockade"],"prefix":"10.1111","volume":"26","author":[{"given":"Srinivas Vinayak","family":"Shenoy","sequence":"first","affiliation":[{"name":"Department of Nephrology Kasturba Medical College, Manipal, Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar 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