{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:27:34Z","timestamp":1767677254391,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Donor\u2010recipient antigen mismatching for anti\u2010human leucocyte antigen (HLA) and MICA is one of the risk factors for antibody induction leading to graft rejection. Our aim was to analyze the incidence and specificity of the different DSAs developing and to investigate the impact of HLA and MICA allele mismatches on antibody production in kidney transplant patients experiencing antibody\u2010mediated rejection (AMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed 253 consecutive recipients of kidney transplant who were diagnosed as experiencing AMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that around 27% of our patients were positive for DSAs over a median follow\u2010up period of 24\u2009months. Antibody to HLA\u2010DQ7 was the most prevalent DSA detected. The allele mismatch number was significantly lower for DQ loci than \u2010A and \u2010B loci (DQ vs. A, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; DQ vs. B, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). Considering each HLA antigen, the incidence rate of DQ\u2010DSA [41.9 (32.92\u201351.46; 95%CI)] was much higher than the rate observed for DSA directed to \u2010A, \u2010DR and \u2010B loci. Half of the recipients in the DQ\u2010DSA\u2010only group, and the DQ\u2010DSA together with non\u2010DQ group, had MFI\u2009&gt;\u20095000. Only one case developed de novo MICA\u2010DSA (MICA002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study indicates that mismatching for HLA and MICA alleles leads to the development of HLA and MICA antibodies in some kidney transplant recipients. We have also demonstrated that DSA to the DQ locus is the most prevalent in kidney transplant patients with AMR. Thus, matching the DQ locus in kidney allocation algorithms may reduce post\u2010transplant development of DSA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13921","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T04:39:21Z","timestamp":1625200761000},"page":"833-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and impact of <scp><i>HLA<\/i><\/scp> and <scp><i>MICA<\/i><\/scp> allele mismatching on donor\u2010specific antibodies induction in kidney transplant rejection"],"prefix":"10.1111","volume":"26","author":[{"given":"Amornrat V.","family":"Romphruk","sequence":"first","affiliation":[{"name":"Blood Transfusion Center, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"},{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences Khon Kaen University  Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5216-8700","authenticated-orcid":false,"given":"Piyapong","family":"Simtong","sequence":"additional","affiliation":[{"name":"The Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences Khon Kaen University  Khon Kaen Thailand"},{"name":"Department of Clinical Immunology and Transfusion Sciences, Faculty of Associated Medical Sciences Khon Kaen University  Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jidpinan","family":"Suntornnipat","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Program, Faculty of Graduate School Khon Kaen University  Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yupaporn","family":"Sudwilai","sequence":"additional","affiliation":[{"name":"Blood Transfusion Center, Faculty of Medicine Khon Kaen University  Khon 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