{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:18Z","timestamp":1747187118505,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited information about the incidence of metabolic acidosis (MA) after renal transplantation. This single centre prospective study aimed to delineate the incidence and risk factors of MA in the first 6\u00a0months after renal transplantation (RTX).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, setting, participants and measurements<\/jats:title><jats:p>Patients who underwent RTX between November 2018 and July 2020 were monitored with weekly measurement of serum bicarbonate level for 6\u00a0months and those who were diagnosed with MA were evaluated further to characterize the type of MA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and twenty\u2010five patients were included in the study, 89 (71.2%) of whom developed MA. Seventy\u2010two patients developed MA in the first month, 11 during the 2\u20133\u00a0months and 6 between 4 and 6\u00a0months after transplantation. Of the 89 patients, 55(61.8%) had type 1 renal tubular acidosis (T1RTA), 27 (30.3%) had type 2 RTA (T2RTA) and 7 (7.9%) type 4 RTA (T4RTA). Two patient who had T1RTA, subsequently developed high anion gap MA following severe graft rejection. On stepwise multivariate regression analysis, serum creatinine at time of diagnosis of MA [OR (95% CI): 12.02 (1.79 to 80.59),<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01] and high tacrolimus C0 levels [OR (95% CI): 2.43 (1.0 to 5.90),<jats:italic>p<\/jats:italic>\u00a0=\u00a0.049], were independent risk factors for MA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a high incidence of MA in the initial 6\u00a0months post\u2010transplant with serum creatinine and high tacrolimus C0 levels being independent risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13954","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T13:24:35Z","timestamp":1627133075000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic acidosis in the initial 6\u00a0months after renal transplantation: A prospective study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9428-9620","authenticated-orcid":false,"given":"Kristin","family":"George","sequence":"first","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish Datt","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-9111","authenticated-orcid":false,"given":"Arun Kumar","family":"Subbiah","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj Kanwar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipankar","family":"Bhowmik","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay Kumar","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1562-9912","authenticated-orcid":false,"given":"Soumita","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.7326\/0003-4819-79-3-352"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1093\/ndt\/gfl211"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1093\/ndt\/gfl714"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1097\/01.tp.0000287430.19960.0e"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.3109\/0886022X.2010.486494"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"5","article-title":"Prevalence and risk factors of renal tubular acidosis after kidney transplantation","volume":"61","author":"Malik SI","year":"2011","journal-title":"J Pak Med Assoc"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.2215\/CJN.04590512"},{"issue":"2","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/ijn.IJN_93_18","article-title":"Post\u2010renal transplant metabolic acidosis: a neglected entity","volume":"29","author":"Fernando ME","year":"2019","journal-title":"Indian J Nephrol"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1210\/endo.143.5.8821"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1681\/ASN.2016070793"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1097\/TXD.0000000000000910"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1053\/j.ajkd.2014.05.008"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1159\/000181840"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1053\/j.ajkd.2018.12.023"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.13954","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.13954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T23:50:13Z","timestamp":1725493813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.13954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/nep.13954"],"URL":"https:\/\/doi.org\/10.1111\/nep.13954","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"type":"print","value":"1320-5358"},{"type":"electronic","value":"1440-1797"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"2021-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}