{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:19:16Z","timestamp":1784819956151,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Left ventricular diastolic dysfunction (LVDD) and LV systolic dysfunction (LVSD) are prevalent in CKD, but their prognostic relevance is debatable.<\/jats:p><jats:p>We intent to verify whether LVDD and LVSD are independently predictive of all\u2010cause mortality and if they have comparable or different effects on outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted of the echocardiographic data of 1285 haemodialysis patients followed up until death or transplantation. LVDD was classified into 4 grades of severity. Endpoint was all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a follow\u2010up of 30\u2009months, 419\/1285 (33%) patients died, 224 (53%) due to CV events. LVDD occurred in 75% of patients, grade 1 DD was the prevalent diastolic abnormality, and pseudonormal pattern was the predominant form of moderate\u2013severe DD. Moderate\u2013severe LVDD (HR 1.379, CI% 1.074\u20131.770) and LVSD (HR 1.814, CI% 1.265\u20132.576) independently predicted death; a graded, progressive association was found between LVDD categories and the risk of death; and the impact of isolated severe\u2013moderate LVDD on the risk of death was comparable to that exercised by isolated compromised LV systolic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Moderate\u2013severe LVDD and LVSD were independently associated with a higher probability of death and had a similar impact on survival. A progressive association was observed between LVDD grades and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13960","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T03:25:47Z","timestamp":1628652347000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Diastolic and systolic left ventricular dysfunction and mortality in chronic kidney disease patients on haemodialysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-3689","authenticated-orcid":false,"given":"Jose J. G.","family":"De Lima","sequence":"first","affiliation":[{"name":"Heart Institute (InCor), Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago A.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Henrique W.","family":"Gowdak","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"David\u2010Neto","sequence":"additional","affiliation":[{"name":"Renal Transplant Unit, Urology, Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A.","family":"Bortolotto","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), Hospital das Cl\u00ednicas University of S\u00e3o Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US Renal Data System USRDS.2002 Annual data report: atlas of end\u2010stage renal disease in the United States. 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