{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:29:11Z","timestamp":1762900151236,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a scarcity of data comparing the consequences of first and second COVID\u201019 waves on kidney transplant recipients (KTRs) in India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010centre retrospective study of 259 KTRs with COVID\u201019 to compare first wave (March 15\u2013December 31 2020, n\u00a0=\u00a0157) and second wave (April 1\u2013May 31 2021, n\u00a0=\u00a0102).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>KTRs during second wave were younger (43 vs. 40\u2009years;<jats:italic>p<\/jats:italic>\u2010value .04) and also included paediatric patients (0 vs. 5.9%;<jats:italic>p<\/jats:italic>\u2010value .003). Symptoms were milder during the second wave (45 vs. 62.7%;<jats:italic>p<\/jats:italic>\u2010value .007); COVID\u201019 positive patients had less frequent cough (32 vs. 13.8%;<jats:italic>p<\/jats:italic>\u2010value .001), fever was less frequent (58 vs. 37%;<jats:italic>p<\/jats:italic>\u2010value .001), and we observed fewer co\u2010morbidities (11 vs. 20.6%;<jats:italic>p<\/jats:italic>\u2010value .04). The percentages of neutrophils (77 vs. 83%;<jats:italic>p<\/jats:italic>\u2010value .001) and serum ferritin (439 vs. 688;<jats:italic>p<\/jats:italic>\u2010value .0006) were higher during second wave, while lymphocyte counts were reduced (20 vs. 14%;<jats:italic>p<\/jats:italic>\u2010value .0001). Hydroxychloroquine (11 vs. 0%;<jats:italic>p<\/jats:italic>\u2010value .0001) and tocilizumab (7 vs. 0%;<jats:italic>p<\/jats:italic>\u2010value .004) were more frequently prescribed during first wave, while utilization of dexamethasone (6 vs. 27%;<jats:italic>p<\/jats:italic>\u2010value .0001) and remdesivir (47 vs. 65%;<jats:italic>p<\/jats:italic>\u2010value .03) increased during the second wave. Mucormycosis (1.3 vs. 10%;<jats:italic>p<\/jats:italic>\u2010value .01) and ICU admissions (20 vs. 37.2%;<jats:italic>p<\/jats:italic>\u2010value .002) were more frequent during second wave. The 28\u2010day mortality rate (9.6 vs. 10%;<jats:italic>p<\/jats:italic>\u2010value 1) was not different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There has been a different clinical spectrum of COVID\u201019 amongst KTR with similar mortality between the two waves at a large Indian transplant centre.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13961","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T11:37:26Z","timestamp":1628681846000},"page":"195-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Consequences of the first and second<scp>COVID<\/scp>\u201019 wave on kidney transplant recipients at a large Indian transplant centre"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-2854","authenticated-orcid":false,"given":"Vivek B.","family":"Kute","sequence":"first","affiliation":[{"name":"Department 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(IKDRC\u2010ITS) Ahmedabad Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nauka","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Sciences Institute of Kidney Diseases and Research Center and Dr HL Trivedi Institute of Transplantation Sciences (IKDRC\u2010ITS) Ahmedabad Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchir B.","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Sciences Institute of Kidney Diseases and Research Center and Dr HL Trivedi Institute of Transplantation Sciences (IKDRC\u2010ITS) Ahmedabad Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-9987","authenticated-orcid":false,"given":"Subho","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Sciences Institute 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