{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:38:35Z","timestamp":1787582315755,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is increasing awareness of the impact of obesity and underweight on cardiovascular (CV) disease, chronic kidney disease (CKD) and mortality. Abnormal body mass index (BMI) might be associated with worse clinical outcomes, including CKD progression, but limited evidence exists among Asian patients with high CV risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association of BMI with progressive loss of kidney function and all\u2010cause mortality in Thai patients with high CV risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a national cohort of 5887 high CV risk subjects, we assessed the association of high BMI with the composite renal outcome (estimated glomerular filtration rate [eGFR] decline over 40%, eGFR less than 15\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, doubling of serum creatinine, initiation of dialysis and death related to renal causes) and with all\u2010cause mortality in Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5887 participants (3217 male and 2670 female) with high CV risk were enrolled. Participants were classified into five groups by their baseline BMI; &lt;20\u2009kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic>\u00a0=\u2009482), 20\u201324.9\u00a0kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic>\u00a0=\u20092437), 25\u201329.9\u00a0kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic>\u00a0=\u20092140), 30\u201334.9\u00a0kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic>\u00a0=\u2009665) and 35\u2009kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic>\u00a0=\u2009163), respectively. On multivariate analysis of Cox proportional hazards models, adjusted for other covariates, baseline BMI \u226535\u2009kg\/m<jats:sup>2<\/jats:sup> was an independent predictor of loss of kidney function (HR 1.60, 95% CI 1.04\u20132.40) and all\u2010cause mortality (HR 2.68, 95% CI 1.50\u20134.80). Baseline BMI &lt;20\u2009kg\/m<jats:sup>2<\/jats:sup> was an independent predictor of all\u2010cause mortality as well (adjusted HR 2.26, 95% CI 1.50\u20133.42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the high CV risk Thai population, a BMI of 35\u2009kg\/m<jats:sup>2<\/jats:sup> or more is associated with loss of kidney function and mortality. On the other hand, a BMI less than 20\u2009kg\/m<jats:sup>2<\/jats:sup> is also associated with all\u2010cause mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.13970","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T09:59:58Z","timestamp":1630403998000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of body mass index with kidney function and mortality in high cardiovascular risk population: A nationwide prospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-7785","authenticated-orcid":false,"given":"Noppawit","family":"Aiumtrakul","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Phramongkutklao Hospital and College of Medicine  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annop","family":"Kittithaworn","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Phramongkutklao Hospital and College of Medicine  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouppatham","family":"Supasyndh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Phramongkutklao Hospital and College of Medicine  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungroj","family":"Krittayaphong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arintaya","family":"Phrommintikul","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8881-0942","authenticated-orcid":false,"given":"Bancha","family":"Satirapoj","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Phramongkutklao Hospital and College of Medicine  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"e_1_2_10_3_1","unstructured":"Prevention CfDCa. 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