{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:22Z","timestamp":1747187122620,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peritoneal dialysis (PD) causes structural and functional changes in the peritoneal membrane, which are attributed to local inflammatory process. This study assessed the presence of galectin\u20103 (Gal\u20103), a known inflammatory modulator, in dialysate effluent and correlated its levels with markers of inflammatory process. Gal\u20103 levels in serum and dialysate effluent were measured in prevalent PD patients on morning visits (<jats:italic>n<\/jats:italic>\u00a0=\u200927) or during peritoneal equilibration tests (PET, <jats:italic>n<\/jats:italic>\u00a0=\u200916), it association with clinical and laboratory parameters, including dialysate\/plasma creatinine (D\/P creatinine) and interleukin\u20106 (IL\u20106) levels was analysed. Gal\u20103 levels in dialysate effluent correlated with D\/P creatinine (0.663, <jats:italic>p<\/jats:italic>\u00a0=\u20090.005) and dialysate effluent IL\u20106 levels (0.674, <jats:italic>p<\/jats:italic>\u00a0=\u20090.002), but not with serum Gal\u20103 levels or dialysis vintage. Patients who were high transporters had higher Gal\u20103 levels in dialysate effluent, as compared to lower transporters. In multivariate regression analysis, dialysate IL\u20106 level was the strongest predictor of dialysate Gal\u20103 levels. This study found Gal\u20103 in dialysate effluent correlated with D\/P creatinine and dialysate IL\u20106 levels. These findings may imply that Gal\u20103 has a role in the intraperitoneal inflammatory process. However, this needs to be investigated further.<\/jats:p>","DOI":"10.1111\/nep.13981","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T23:52:10Z","timestamp":1633650730000},"page":"104-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Presence of galectin\u20103 in peritoneal dialysate. Does it have a role in the peritoneal membrane inflammatory process?"],"prefix":"10.1111","volume":"27","author":[{"given":"Yael","family":"Einbinder","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension Meir Medical Center  Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayala","family":"Siboni","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Meir Medical Center  Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Zaidenstein","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Meir Medical Center  Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren","family":"Cohen\u2010Hagai","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Meir Medical 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