{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T03:09:05Z","timestamp":1773716945537,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Pregnancy\u2010associated hemolytic uremic syndrome (P\u2010aHUS) is an important cause of peripartum acute kidney injury. Studies from Europe have described mutations in complement regulator genes, and data in Indian patients is scarce. Hence this study used multiplex ligation\u2010dependent probe amplification (MLPA) to identify variants in complement genes in P\u2010aHUS patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>We present 17 patients of P\u2010aHUS who were investigated for complement protein levels and genetic analysis with MLPA for complement genes. Plasma exchange therapy was offered to all patients presenting in acute phase.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age 26.74 (3.36) years with 15\/17 delivered by caesarean section. Eleven patients received early (within 7\u2009days) plasma exchange, three were dialysis\u2010dependent at 3\u00a0months and seven were dialysis\u2010free. Only one of the three patients receiving late (after 7\u2009days) plasma exchange was dialysis\u2010free. MLPA showed that 11 patients had heterozygous deletions of exons 3, 5, 6 of CFHR1<\/jats:italic> and upstream region of exons 1, 2, 3, 6 and intron 4 of CFHR3<\/jats:italic> gene while four patients had homozygous deletions at the same loci. Two patients had no MLPA\u2010detectable variations.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study reports a high proportion of deletions of exons of CFHR1<\/jats:italic> & CFHR3<\/jats:italic> genes in Indian P\u2010aHUS patients detectable by MLPA by copy number variations. This needs confirmation in large multicentre studies. Plasma exchange can be an effective therapy in the non\u2010availability of Eculizumab.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14004","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T09:00:08Z","timestamp":1637312408000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High prevalence of CFHR<\/i><\/scp> deletions in Indian women with pregnancy\u2010associated hemolytic uremic syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"Sharon","family":"Kandari","sequence":"first","affiliation":[{"name":"Renal Unit KEM Hospital Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-4200","authenticated-orcid":false,"given":"Vipul","family":"Chakurkar","sequence":"additional","affiliation":[{"name":"Renal Unit KEM Hospital Pune 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