{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:55:17Z","timestamp":1768074917294,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003803","name":"University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Type 2 diabetes (T2D) is associated with significant cardiovascular (CV) morbidity and mortality. A single\u2010nucleotide polymorphism (SNP) in the acetyl\u2010coenzyme A carboxylase beta (<jats:italic>ACACB<\/jats:italic>) gene, rs2268388, reproducibly associates with diabetic nephropathy (DN). <jats:italic>ACACB<\/jats:italic> regulates fatty\u2010acid oxidation. As such, we assessed whether <jats:italic>ACACB<\/jats:italic> SNP rs2268388 was associated with CV disease in Chinese individuals with T2D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Chinese individuals with T2D were genotyped for SNP rs2268388. Baseline demographics were recorded and clinical data regarding coronary, carotid, and peripheral arterial disease and congestive heart failure were retrieved from electronic patient records. Statistical analyses were performed to detect associations between the rs2268388 T risk allele with CV outcomes in the cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 596 Chinese individuals with T2D were genotyped. Their mean age was 66.8\u2009\u00b1\u200910.9\u2009years at the time of data extraction. Genotyping revealed 59.7%, 33.2% and 7.1% of the study population were non\u2010carriers, heterozygous and homozygous carriers of the rs2268388 T risk allele in <jats:italic>ACACB<\/jats:italic>. No statistically significant correlations of the risk allele were observed with CV outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results did not demonstrate association between rs2268388 SNP in <jats:italic>ACACB<\/jats:italic> with CV outcomes in Chinese T2D patients. The <jats:italic>ACACB<\/jats:italic> gene and its role in CV risk susceptibility, via alterations in fatty acid oxidation, remains an interesting postulate and studies with larger cohort sizes and in different ethnic groups remain warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14017","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T05:17:51Z","timestamp":1640236671000},"page":"404-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Acetyl\u2010coenzyme<\/scp> A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6241-1145","authenticated-orcid":false,"given":"Gary C. W.","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine The University of Hong Kong  Pok Fu Lam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Clinical Research Methodology Unit Li Ka Shing Faculty of Medicine, University of Hong Kong  Pok Fu Lam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Centers for Genomics and Personalized Medicine Research &amp; Diabetes Research Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry I.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Nephrology Wake Forest School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-1941","authenticated-orcid":false,"given":"Sydney C. W.","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine The University of Hong Kong  Pok Fu Lam Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.10.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000842"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1460-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq303"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.08.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056193"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1733877100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1056843"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800079-JLR200"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2019.101020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.16.10669"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409451102"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.14017","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:40:03Z","timestamp":1692985203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.14017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/nep.14017"],"URL":"https:\/\/doi.org\/10.1111\/nep.14017","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]},"assertion":[{"value":"2021-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}