{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:28Z","timestamp":1747187128564,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Despite advancements in diabetic care, diabetic kidney transplant recipients have significantly worse outcomes than non\u2010diabetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our study aims to demonstrate the impact of diabetes, types I and II, on American young adults (18\u201340\u2009years old) requiring kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the United Network for Organ Sharing database, we conducted a population cohort study that included all first\u2010time, kidney\u2010only transplant recipients during 2002\u20132019, ages 18\u201340\u2009years old. Patients were grouped according to indication for transplant. Primary outcomes were cumulative all\u2010cause mortality and death\u2010censored graft failure. Death\u2010censored graft failure and patient survival at 1, 5, and 10\u2009years were calculated via the Kaplan\u2013Meier method. Multivariate Cox regression was used to assess for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 42\u2009466 transplant recipients, 3418 (8.1%) had end\u2010stage kidney disease associated with diabetes. At each time\u2010point, cumulative mortality was higher in diabetics compared to patients with non\u2010diabetic causes of renal failure. Conversely, cumulative graft failure was similar between the groups. Adjusted hazard ratios for all\u2010cause mortality and graft failure in diabetics were 2.99 (95% CI 2.67\u20133.35; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) and 0.98 (95% CI 0.92\u20131.05, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diabetes mellitus in young adult kidney transplant recipients is associated with a nearly three\u2010fold increase in mortality, reflecting a relatively vulnerable patient population. Identifying the underlying causes of poor outcomes in this population should be a priority for future study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14019","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T08:15:37Z","timestamp":1641370537000},"page":"450-457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of diabetes on young transplant recipients: An American perspective"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-8445","authenticated-orcid":false,"given":"Jackquelin M.","family":"Loera","sequence":"first","affiliation":[{"name":"Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer C.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore S.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrish","family":"Anand","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A. Y.","family":"Awan","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant Surgery Baylor St. Luke's Medical Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhamidipati V. 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DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"},{"name":"Division of Abdominal Transplant Surgery Baylor St. Luke's Medical Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30058-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30317-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3210"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1162"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495081"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.4.421"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2455"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0991"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.70"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.02.012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001962"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30404-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.04.043"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00816.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.205"},{"issue":"4","key":"e_1_2_7_17_1","first-page":"1025","article-title":"Primary renal disease in young adults with renal failure","volume":"25","author":"Neild GH","year":"2010","journal-title":"Nephrol Dial Transpl Off Publ Eur Dial Transpl Assoc\u2014Eur Ren Assoc"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0211"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874303X014070100133"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09801"},{"issue":"3","key":"e_1_2_7_22_1","first-page":"235","article-title":"Type 2 diabetes mellitus in children and adolescents: a relatively new clinical problem within pediatric practice","volume":"9","author":"Temneanu OR","year":"2016","journal-title":"J Med Life"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10030"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20597"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4930157"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-6702-8"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0056"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.14019","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:40:14Z","timestamp":1692985214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.14019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/nep.14019"],"URL":"https:\/\/doi.org\/10.1111\/nep.14019","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"type":"print","value":"1320-5358"},{"type":"electronic","value":"1440-1797"}],"subject":[],"published":{"date-parts":[[2022,1,18]]},"assertion":[{"value":"2021-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}