{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:34:51Z","timestamp":1790948091819,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Recently, we demonstrated the efficacy of etelcalcetide in the control of secondary hyperparathyroidism (SHPT). This <jats:italic>post hoc<\/jats:italic> analysis aimed to evaluate changes in fibroblast growth factor\u201023 (FGF23) and calciprotein particles (CPPs) after treatment with calcimimetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The DUET trial was a 12\u2010week multicenter, open\u2010label, parallel\u2010group, randomized (1:1:1) study with patients treated with etelcalcetide plus active vitamin D (E\u2009+\u2009D group; <jats:italic>n<\/jats:italic>\u00a0=\u200941), etelcalcetide plus oral calcium (E\u2009+\u2009Ca group; <jats:italic>n<\/jats:italic>\u00a0=\u200941), or control (C group; <jats:italic>n<\/jats:italic>\u00a0=\u200942) under maintenance haemodialysis. Serum levels of FGF23 and CPPs were measured at baseline, and 6 and 12\u2009weeks after the start.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the linear mixed model, serum levels of FGF23 in etelcalcetide users were significantly lower than those in non\u2010users at week 6 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) and week 12 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). When compared the difference between the E\u2009+\u2009Ca group and the E\u2009+\u2009D group, serum levels of FGF23 in the E\u2009+\u2009Ca group were significantly lower than those in the E\u2009+\u2009D group at week 12 (<jats:italic>p<\/jats:italic>\u00a0=\u2009.017). There were no significant differences in the serum levels of CPPs between etelcalcetide users and non\u2010users at week 6 and week 12, while CPPs in the E\u2009+\u2009Ca group were significantly lower than those in the E\u2009+\u2009D group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) at week 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Etelcalcetide may be useful through suppression of FGF23 levels among haemodialysis patients with SHPT. When correcting hypocalcaemia, loading oral calcium preparations could be more advantageous than active vitamin D for the suppression of both FGF23 and CPPs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14081","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T16:09:31Z","timestamp":1656086971000},"page":"763-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of etelcalcetide on fibroblast growth factor\u201023 and calciprotein particles in patients with secondary hyperparathyroidism undergoing haemodialysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Yusaku","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Nephrology Nagoya University Graduate School of Medicine  Aichi 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