{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:04:17Z","timestamp":1793329457775,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The recent IN.PACT AV Access study found drug\u2010coated balloon therapy to be associated with reduced reinterventions compared to percutaneous transluminal angioplasty using standard balloons in the management of arteriovenous fistula stenosis. The economic implications of drug\u2010coated balloon use in Asia, including Japan and Korea, remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A decision\u2010analytic model was developed to calculate strategy\u2010specific costs for Korea and Japan through 5\u2010year follow\u2010up. The analysis assumed maintained therapy benefit beyond current trial follow\u2010up of 1 year in the base case, with several alternative scenarios explored in sensitivity analysis. Costs were derived from claims and reimbursement data, and projections were evaluated at 3 and 5\u2009years post\u2010index procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Model\u2010projected access circuit reintervention events for drug\u2010coated versus standard balloons were 1.70 versus 2.76 (\u22121.06) and 2.53 versus 4.10 (\u22121.57) at 3 and 5\u2009years in the base case. Corresponding 3\u2010 and 5\u2010year costs were \u20a96\u2009211\u2009103 versus \u20a97\u2009605\u2009553 (\u2212\u20a91\u2009394\u2009451) and \u20a97\u2009766\u2009051 versus \u20a910\u2009124\u2009954 (\u2212\u20a92\u2009358\u2009904) in Korea, and \u00a51\u2009469\u2009824 versus \u00a51\u2009504\u2009161 (\u2212\u00a534\u2009337) and \u00a51\u2009956\u2009931 versus \u00a52\u2009106\u2009632 (\u2212\u00a5149\u2009701) in Japan. In scenario analyses, drug\u2010coated balloons remained cost saving at 3\u2010 and 5\u2010year follow\u2010up in Korea, but required up to 5\u2009years to reach cost\u2010savings in Japan. Drug\u2010coated balloon use in reinterventions increased projected savings, as did younger treatment age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment of arteriovenous fistulas with the IN.PACT AV drug\u2010coated balloon, based on preliminary data, may lead to meaningful reductions in reintervention costs that would render it cost\u2010saving at timeframes of around 1 year in Korea and between 3 and 5\u2009years in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14085","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T18:04:11Z","timestamp":1660241051000},"page":"859-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Economics of drug\u2010coated balloons for arteriovenous fistula stenosis in Japan and Korea based on the <scp>IN<\/scp>.<scp>PACT AV<\/scp> access trial"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-6152","authenticated-orcid":false,"given":"Ho Jong","family":"Chun","sequence":"first","affiliation":[{"name":"Department of Radiology The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-1072","authenticated-orcid":false,"given":"Khoa N.","family":"Cao","sequence":"additional","affiliation":[{"name":"Wing Tech Inc.  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Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8170-4960","authenticated-orcid":false,"given":"Andrew","family":"Holden","sequence":"additional","affiliation":[{"name":"Department of Radiology Auckland Hospital  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-1939","authenticated-orcid":false,"given":"Jan B.","family":"Pietzsch","sequence":"additional","affiliation":[{"name":"Wing Tech Inc.  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