{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:08:53Z","timestamp":1769573333378,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To describe an experience using a protocol using de novo belatacept (DNB) based maintenance immunosuppression in the setting of lymphocyte depletion. A retrospective, observational study was performed on 37 kidney transplant recipients treated with the DNB protocol, which was defined as belatacept initiated within 7\u2009days after a kidney transplant with steroids and mycophenolate with anti\u2010thymocyte globulin (ATG) induction without concomitant calcineurin inhibitors (CNIs). Patients who received a deceased donor kidney meeting one or more of the following criteria: anticipated cold ischemia time (CIT) greater than 24\u2009h, donation after cardiac death, donor acute kidney injury, and a Kidney Donor Profile Index (KDPI)\u2009&gt;85% during the study period were included. Patient survival at 1\u00a0year was 97.3% and graft survival was 94.6%. Delayed graft function (DGF) occurred in 40.54% of the patients. Two patients experienced a Banff 1B acute cellular rejection. BK viremia was detected in 32.4% of patients. The mean estimated glomerular filtration rate (eGFR) calculated with the use of modification of diet in renal disease (MDRD) equation at 1\u00a0year in the study group was 54.7\u00a0ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>. We believe that utilization of the DNB protocol, which allows early CNI avoidance, may decrease organ discard rates.<\/jats:p>","DOI":"10.1111\/nep.14106","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T13:44:04Z","timestamp":1662039844000},"page":"901-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes of de novo belatacept\u2010based immunosuppression regimen and avoidance of calcineurin inhibitors in recipients of kidney allografts at higher risk for underutilization"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5535-9908","authenticated-orcid":false,"given":"Ankita","family":"Patel","sequence":"first","affiliation":[{"name":"Nephrology Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Shertel","sequence":"additional","affiliation":[{"name":"Pharmacy Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wynd","sequence":"additional","affiliation":[{"name":"Pharmacy Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Wadhera","sequence":"additional","affiliation":[{"name":"Surgery Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Serur","sequence":"additional","affiliation":[{"name":"Nephrology Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Schleich","sequence":"additional","affiliation":[{"name":"Quality Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriy","family":"Yushkov","sequence":"additional","affiliation":[{"name":"Surgery Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Surgery Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12394"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"20","article-title":"OPTN\/SRTR 2018 Annual Data Report: Kidney","volume":"20","author":"Hart A","year":"2019","journal-title":"Am J Transplant"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13709"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN108858"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13769"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001405"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04800908"},{"issue":"4","key":"e_1_2_7_10_1","first-page":"375","article-title":"Profile of belatacept and its potential role in prevention of graft rejection following renal transplantation","volume":"1","author":"Gupta G","year":"2010","journal-title":"Drug des Devel Ther"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.03005.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03016.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.02.016"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017030238"},{"key":"e_1_2_7_16_1","unstructured":"https:\/\/www.srtr.org\/reports\/opo-specific-reports\/opo?code=NJTO"},{"key":"e_1_2_7_17_1","unstructured":"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/125288s075lbl.pdf"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03338.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13100820"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2002.00075.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00742.x"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.14106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:20:13Z","timestamp":1692674413000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.14106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/nep.14106"],"URL":"https:\/\/doi.org\/10.1111\/nep.14106","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,11]]},"assertion":[{"value":"2022-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}