{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:42Z","timestamp":1747187142165,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the additional utility of pre\u2010nephrectomy whole and cortical kidney volumes (WKV, CKV) in predicting long\u2010term post\u2010nephrectomy kidney function in Indian living kidney donors (LKDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included all LKDs who underwent nephrectomy between 1 January 2006 and 31 December 2015 at our centre, had pre\u2010nephrectomy height, weight and computed tomography (CT) angiography with arterial and nephrographic phase documented, and 5\u2010year post\u2010nephrectomy creatinine values measured. Correlation between body surface area (BSA) adjusted pre\u2010nephrectomy total CKV, WKV and pre\u2010nephrectomy CKD EPI eGFR; BSA\u2010adjusted remnant pre\u2010nephrectomy CKV (rCKV), WKV (rWKV) and 5\u2010year post\u2010nephrectomy CKD EPI creatinine eGFR (5yeGFR<jats:sub>Cr<\/jats:sub>); predictors of 5yeGFR<jats:sub>Cr<\/jats:sub>\u2009&lt;\u200970% of pre\u2010nephrectomy CKD EPI creatinine eGFR (pre\u2010eGFR<jats:sub>Cr<\/jats:sub>), and an equation to predict 5yeGFR<jats:sub>Cr<\/jats:sub> from pre\u2010nephrectomy variables were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 196 LKDs (74% female, mean age 41.7\u2009\u00b1\u200911.0\u2009years) were included in the study. Total WKV showed higher correlation with pre\u2010nephrectomy eGFR than CKV, the highest with CKD EPI cystatin eGFR. Remnant WKV showed higher correlation than rCKV with post\u2010nephrectomy eGFR<jats:sub>Cr<\/jats:sub> and this increased over time. Older age, lower rWKV or rCKV, higher BSA, and higher pre\u2010eGFR<jats:sub>Cr<\/jats:sub> identified LKDs with 5yeGFR<jats:sub>Cr<\/jats:sub>\u2009&lt;\u200970% of pre\u2010eGFR<jats:sub>Cr<\/jats:sub>, with rCKV identifying a higher proportion (4.5%) of such LKDs. A model including rWKV or rCKV predicted 5yeGFR<jats:sub>Cr<\/jats:sub> better than one including age, gender, BSA and pre\u2010eGFR<jats:sub>Cr<\/jats:sub> alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inclusion of pre\u2010nephrectomy remnant CKV and WKV into models for 5yeGFR<jats:sub>Cr<\/jats:sub> and sub\u2010optimal post\u2010nephrectomy adaptation in Indian LKDs improves their accuracy. CKD EPI cystatin eGFR correlates better with functional renal mass.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14129","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T16:03:55Z","timestamp":1667837035000},"page":"136-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole and cortical kidney volume predict 5\u2010year post\u2010nephrectomy <scp>eGFR<\/scp> in <scp>I<\/scp>ndian living kidney donors"],"prefix":"10.1111","volume":"28","author":[{"given":"Reettika","family":"Chanda","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Christian Medical College  Vellore Tamil Nadu 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