{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:42Z","timestamp":1747187142642,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beta Trace Protein (BTP) is a biomarker for residual kidney function which has been linked to cardiovascular and all\u2010cause mortality in haemodialysis patients. Following renal transplantation, recipients remain at increased risk for cardiovascular events compared with the general population. We aimed to determine the relationship of pre\u2010transplant BTP to major adverse cardiac events (MACE) in patients following kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 384 patients with end\u2010stage renal disease who received a kidney transplant. MACE was defined as myocardial infarction (ST\u2010segment elevation or non\u2010ST\u2010segment elevation, stroke or transient ischemic attack), coronary artery disease requiring intervention or bypass or death for cardiovascular reason. The association between pre\u2010transplant serum BTP concentration and post\u2010transplant MACE was evaluated by Kaplan\u2013Meier and Cox regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010transplant MACE occurred in 70\/384 patients. Pre\u2010transplant BTP was significantly higher in patients with post\u2010transplant MACE (14.36\u2009\u00b1\u20095.73\u2009mg\/l vs. 11.26\u2009\u00b1 5.11\u2009mg\/l; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Next to smoking (HR 1.81), age\u2009&gt;\u200956.38\u2009years (HR 1.97) and pre\u2010existing coronary heart disease (HR 8.23), BTP above the cut off value of 12.7\u2009mg\/l was confirmed as independent risk factor for MACE (HR 2.02, all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). MACE\u2010free survival inversely correlated with pre\u2010transplant BTP levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010transplant serum BTP concentration may identify renal transplant recipients with higher risk of post\u2010transplant MACE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14131","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T07:29:41Z","timestamp":1668238181000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>Pre\u2010transplant<\/scp> serum Beta Trace Protein indicates risk for post\u2010transplant major cardiac adverse events"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7504-4436","authenticated-orcid":false,"given":"Sebastian","family":"Schwab","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"},{"name":"Institute of Experimental Immunology University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"P\u00f6rner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola\u2010Ellen","family":"Kleine","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Werberich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Werberich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"B\u00f6s","sequence":"additional","affiliation":[{"name":"Kuratorium for Dialysis KfH Renal Center  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian P.","family":"Strassburg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibylle","family":"von Vietinghoff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer P.","family":"Woitas","sequence":"additional","affiliation":[{"name":"Diaverum Deutschland GmbH  Munich 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