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In 640 adult participants of the Heart and Soul Study (mean baseline age of 66.2\u2009years) with a high prevalence cardiovascular disease, hypertension and diabetes, we examined the association of PTSD with GFR decline over a 5\u2010year follow\u2010up. We observed a significantly greater estimated (e) GFR decline over time in those with PTSD compared to those without (2.97 vs. 2.11\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>\/year; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022). PTSD was associated with 91% (95% CI 12%\u2013225%) higher odds of \u2018rapid\u2019 versus \u2018mild\u2019 (&gt;3.0 vs. &lt;3.0\u00a0ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>\/per year) eGFR decline. These associations remained consistent despite controlling for demographics, medical comorbidities, other mental disorders and psychiatric medications. In conclusion, our study provides evidence that PTSD is independently associated with GFR decline in middle\u2010aged adults with a high comorbidity burden. This association needs to be examined in larger cohorts with longer follow\u2010ups.<\/jats:p>","DOI":"10.1111\/nep.14140","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T14:08:31Z","timestamp":1672754911000},"page":"181-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The association of post\u2010traumatic stress disorder with glomerular filtration rate decline"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6974-5674","authenticated-orcid":false,"given":"Farrukh M.","family":"Koraishy","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Stony Brook University  Stony Brook New York USA"},{"name":"Department of Medicine Northport VA Medical Center  Northport New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth E.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California  San Francisco California USA"},{"name":"Department of Medicine San Francisco VA Health Care System  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery F.","family":"Scherrer","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Whooley","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California  San Francisco California USA"},{"name":"Department of Medicine San Francisco VA Health Care System  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos","family":"Hajagos","sequence":"additional","affiliation":[{"name":"Department of Medical Bioinformatics Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassianne","family":"Robinson\u2010Cohen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Family, Population, and Preventive Medicine, Program in Public Health Stony Brook University  Stony Brook New York 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