{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:51:21Z","timestamp":1767649881260,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Calciphylaxis is a rare disease, predominantly in chronic kidney disease (CKD), characterized by high morbidity and mortality. Data from the Chinese population have been an invaluable resource for a better understanding of natural history, optimal treatments and outcomes of calciphylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted in 51 Chinese patients diagnosed with calciphylaxis at Zhong Da Hospital affiliated to Southeast University from December 2015 to September 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2015 and 2020, 51 cases of calciphylaxis were registered in The China Calciphylaxis Registry (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.calciphylaxis.com.cn\">http:\/\/www.calciphylaxis.com.cn<\/jats:ext-link>), which was developed by Zhong Da Hospital. The mean age of the cohort was 52.02\u2009\u00b1\u200914.09\u2009years, and 37.3% were female. Forty\u2010three patients (84.3%) were on haemodialysis, with a median dialysis vintage of 88\u2009months. Eighteen patients (35.3%) had a resolution of calciphylaxis and 20 patients (39.2%) died. Patients in later stages had higher overall mortality than those in earlier stages. Delay from skin lesions onset to diagnosis and calciphylaxis\u2010related infections were risk factors in both early and overall mortality. Additionally, dialysis vintage and infections were significant risk factors in calciphylaxis\u2010specific mortality. Among therapeutic strategies, only the use of sodium thiosulfate (STS) \u22653 courses (14 injections) was significantly associated with decreased hazard of death in both early and overall mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For Chinese patients with calciphylaxis, delay from skin lesions onset to diagnosis and infections secondary to wounds are risk factors for the prognosis of patients with calciphylaxis. Additionally, patients in earlier stages have better survival and early continuous use of STS is highly suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14156","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T14:50:11Z","timestamp":1678287011000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical features and outcomes of calciphylaxis in Chinese patients with chronic kidney disease"],"prefix":"10.1111","volume":"28","author":[{"given":"Yongyi","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Nephrology, Zhong Da Hospital Southeast University School of Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology Xuyi People's Hospital  Huaian 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