{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:07:33Z","timestamp":1791223653036,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572572"],"award-info":[{"award-number":["31572572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Inflammation and apoptosis are main pathological processes that lead to the development of hyperuricemic nephropathy (HN). This study aims to explore whether baicalin (BA) and baicalein (BAI) can relieve the damage through PI3K\/AKT\/NF\u2010\u03baB signal pathway and provide more reliable and precise evidence for the treatment of HN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HN mice were induced by yeast extract with potassium oxonate (PO), and HK\u20102 cells were induced by monosodium urate (MSU). Molecular docking, western blot, q\u2010PCR, and other methods were used to explore the changes of various indicators in HN mice and HK\u20102 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Molecular docking results showed that BA and BAI had good binding ability with PI3K, AKT, p65 and I\u03baB\u03b1. BA and BAI significantly ameliorated the levels of renal function, decreased the p\u2010PI3K, p\u2010AKT and p\u2010p65 expression, down\u2010regulated the BAX\/BCL2 and CASP3, and blunted the mRNA levels of tumour necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20101\u03b2, and IL\u201018 in both renal tissue of HN mice and HK\u20102 cells induced by MSU. BA and BAI also decreased the oxidative stress level of MSU\u2010induced HK\u20102 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BA and BAI were confirmed to attenuate HN through alleviating renal inflammatory and apoptosis in cells and tissues by inhibiting PI3K\/AKT\/NF\u2010\u03baB pathway. BA and BAI were expected to be developed as new anti\u2010HN drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14159","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T07:11:06Z","timestamp":1679987466000},"page":"315-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting <scp>PI3K<\/scp>\/<scp>AKT<\/scp>\/<scp>NF\u2010\u03baB<\/scp> signalling pathway"],"prefix":"10.1111","volume":"28","author":[{"given":"Ziyuan","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Wuhan Polytechnic University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilong","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Wuhan Polytechnic University  Wuhan 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