{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:20:18Z","timestamp":1790508018616,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to investigate the incidence of relapse and FR\/SDNS in Chinese children with SSNS and to develop clinical prediction models for relapse and FR\/SDNS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study involved 339 newly onset SSNS patients between 2006 and 2016. The incidence of relapse and FR\/SDNS were estimated using the Kaplan\u2013Meier method. Prediction models were constructed based on Cox proportional\u2010hazards regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 8.7\u2009years. The cumulative incidence of relapse at 1\u2010, 2\u2010, and 5\u2010year was 51.0%, 62.5%, and 66.6%. The cumulative incidence of FR\/SDNS at 1\u2010, 2\u2010, and 5\u2010year was 18.4%, 29.0%, and 32.9%. The final prediction model for first relapse included four variables (serum albumin, triglycerides, IgM, and time to first remission). The model's discriminative ability was low (Harrell's C index\u2009=\u20090.62). The final prediction model for FR\/SDNS included four variables (serum albumin, lipoprotein(a), time to first remission, and time to first relapse). The discrimination and calibration of the prediction model for FR\/SDNS were acceptable (Harrell's C index\u2009=\u20090.73, Brier score at 1\u2010 and 2\u2010year were 0.11 and 0.17).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The first relapse and FR\/SDNS mainly occurred in the first 2\u2009years after initial SSNS onset. The prediction model for relapse developed using common clinical parameters performed poorly, while the prediction model for FR\/SDNS might be useful.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14187","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T05:40:51Z","timestamp":1685511651000},"page":"477-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence of relapse and frequently relapsing\/steroid\u2010dependent nephrotic syndrome in Chinese children with steroid\u2010sensitive nephrotic syndrome: A cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-1724","authenticated-orcid":false,"given":"Daojing","family":"Ying","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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