{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:27:05Z","timestamp":1764588425784,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2705101"],"award-info":[{"award-number":["2022YFC2705101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The modified semiquantitative classification (SQC) is a new pathological classification for Henoch\u2013Sch\u00f6nlein purpura nephritis (HSPN), and its prognostic value with regard to the outcomes of HSPN is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of 249 patients with biopsy\u2010proven HSPN admitted to the Children's Hospital of Chongqing Medical University. In addition to the International Study of Kidney Disease in Children (ISKDC) classification, renal biopsy specimens were also reevaluated according to the SQC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the follow\u2010up period of 2.9 (1.0\u20136.9)\u2009years, 14 (5.6%) patients reached the poor outcome at the end of follow\u2010up. The SQC activity and chronicity indexes were positively correlated with the clinical manifestations, conventional pathology grades, and 24\u2010h urinary protein (24hUP). The difference in the areas under the curve between the total biopsy SQC scores and ISKDC classification was 0.12 (<jats:italic>p<\/jats:italic>\u2009=\u2009.001, 95% CI: 0.0485\u20130.192). In the receiver operating characteristic (ROC) curve analysis of 1\u2010year, 3\u2010year, and 5\u2010year poor outcomes and total biopsy SQC scores, a total biopsy score \u226510 was associated with a higher risk of an adverse outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that the SQC indexes are clearly correlated with the clinical and pathological findings of HSPN. The SQC is more sensitive than ISKDC classification for the prediction of the long\u2010term outcomes of HSPN in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14193","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T05:41:36Z","timestamp":1686894096000},"page":"495-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Value of the modified semiquantitative classification in predicting outcomes in children with Henoch\u2013Sch\u00f6nlein purpura nephritis"],"prefix":"10.1111","volume":"28","author":[{"given":"Yuhao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatric Medicine Hangzhou Children's Hospital  Hangzhou Zhejiang China"},{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junli","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daoqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaofu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Pediatrics  Chongqing China"},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelan","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing 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