{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:56:17Z","timestamp":1793055377904,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:00:00Z","timestamp":1697846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21\u201074\u201020173"],"award-info":[{"award-number":["21\u201074\u201020173"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are podocytopathies characterized by damage to the glomerular filtration barrier, leading to proteinuria and nephrotic syndrome. The production of anti\u2010podocyte antibodies has been proposed as potential circulating factors contributing to the development of these conditions. The aim of the study is to evaluate the levels of anti\u2010nephrin antibodies in patients with podocytopathies and healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, a total of 77 patients with active glomerulopathy and 11 healthy subjects were included. Forty one patients were diagnosed with FSGS, 11 with MCD, and 25 with MN. To measure the levels of anti\u2010nephrin antibodies, enzyme\u2010linked immunosorbent assay was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The levels of antibodies to nephrin were significantly higher in patients with MCD 61.2 [28.9\u201366.3] ng\/mL and FSGS 32.5 [17.2\u201358.4] ng\/mL compared to MN 20.3 [14.4\u201338.4] and healthy individuals 15.3 [12\u201318.9] ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05. In patients with primary FSGS, the levels of antibodies to nephrin were significantly higher 45.2 [20\u201364.3] ng\/mL compared to patients with secondary FSGS 26.7 [11.2\u201344.1] ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05. There were no significant differences in the remission rate between the anti\u2010nephrin antibodies positive and negative groups (log\u2010rank test:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.158).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The level of anti\u2010nephrin antibodies was found to be significantly higher in patients with MCD and pFSGS compared to those with sFSGS, MN, and healthy subjects. Anti\u2010nephrin antibodies in MCD and primary FSGS may be associated with the severity of podocytopathies, however they did not have an impact on the response to therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.14249","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T06:34:25Z","timestamp":1697870065000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A pilot study of anti\u2010nephrin antibodies in podocytopaties among adults"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-8560","authenticated-orcid":false,"given":"Natalia","family":"Chebotareva","sequence":"first","affiliation":[{"name":"Tareev Clinic of Internal Diseases Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoliy","family":"Vinogradov","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Lomonosov Moscow State University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgeniya","family":"Birukova","sequence":"additional","affiliation":[{"name":"Tareev Clinic of Internal Diseases Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Alentov","sequence":"additional","affiliation":[{"name":"Department of Prediction of Conservative Treatment Efficiency Hertsen Moscow Oncology Research Institute  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sergeeva","sequence":"additional","affiliation":[{"name":"Department of Prediction of Conservative Treatment Efficiency Hertsen Moscow Oncology Research Institute  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Chemodanova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Lomonosov Moscow State University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey S.","family":"Kononikhin","sequence":"additional","affiliation":[{"name":"Center for Molecular and Cellular Biology Skolkovo Institute of Science and Technology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Moiseev","sequence":"additional","affiliation":[{"name":"Tareev Clinic of Internal Diseases Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010006\u20100370\u20105"},{"issue":"4","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","article-title":"KDIGO 2021 clinical practice guideline for the management of glomerular diseases","volume":"100","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group","year":"2021","journal-title":"Kidney Int"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05960616"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017090958"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604043341402"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1202500"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/714964"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201083883\u2010w"},{"issue":"5","key":"e_1_2_8_10_1","first-page":"811","article-title":"T and B cells immunophenotypes in blood and urine of patients with focal segmental glomerulosclerosis in relation to disease severity","volume":"15","author":"Anis S","year":"2018","journal-title":"Clin Pract"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010017\u20103677\u20105"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.2005.02862.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201021\u20103988"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.12.014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008538"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021060794"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfy067"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60541-9"},{"issue":"27","key":"e_1_2_8_19_1","first-page":"1","article-title":"Heredity in the congenital nephrotic syndrome. 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