{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:47:30Z","timestamp":1771026450305,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K11199"],"award-info":[{"award-number":["JP21K11199"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Circulating blood volume (BV) during exercise changes depending on the intensity and duration, and post\u2010exercise hypotension is observed after continuous exercise. We investigated the safety and efficacy of both interval and continuous IDE at anaerobic threshold (AT) levels with respect to hemodynamic stability and dialysis efficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this crossover randomized controlled trial, 16 patients on haemodialysis were subjected to three trial arms, including non\u2010IDE, interval\u2010IDE, and continuous\u2010IDE arms. Systolic blood pressure (SBP), BV, and ultraviolet absorbance \u2013 an indicator of dialysis efficiency \u2013 were continuously measured, and each change was compared between the three arms by two\u2010way analysis of variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Continuous IDE decreased SBP from post\u2010exercise to the end of dialysis compared with baseline (pre 142.8\u2009\u00b1\u200919.0 vs. post 127.5\u2009\u00b1\u200924.5\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u2009.02), whereas interval IDE maintained better SBP levels post\u2010exercise (pre 139.9\u2009\u00b1\u200917.1 vs. post 140.1\u2009\u00b1\u200915.8\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20091.0) than continuous IDE (non\u2010IDE 133.2\u2009\u00b1\u200919.9 vs. interval 140.1\u2009\u00b1\u200915.8 vs. continuous 127.5\u2009\u00b1\u200924.5\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u2009.04). Moreover, interval IDE caused less tiredness and few symptoms (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), despite reaching higher intensity than continuous IDE (<jats:italic>p<\/jats:italic>\u2009=\u2009.001). The BV of each IDE arm decreased during exercise and recovered post\u2010exercise to the same level as non\u2010IDE. Ultraviolet absorbance was not different between each arm (<jats:italic>p<\/jats:italic>\u2009=\u2009.16).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AT\u2010level interval IDE maintains better hemodynamic stability from post\u2010exercise to the end of dialysis and may represent a novel approach that can be effectively performed with fewer symptoms.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/nep14255-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14255","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T18:48:57Z","timestamp":1700678937000},"page":"214-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of intradialytic continuous and interval training on hemodynamics and dialysis adequacy: A crossover randomized controlled trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-0972","authenticated-orcid":false,"given":"Naoto","family":"Usui","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Kisen Hospital  Tokyo Japan"},{"name":"Department of Nephrology, Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichiro","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akimi","family":"Uehata","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kisen Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Kisen Hospital  Tokyo Japan"},{"name":"Institute for Human Movement and Medical Sciences Niigata University of Health and Welfare  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Health Science Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Kisen Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Information Sciences Tokyo University of Science  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Inatsu","sequence":"additional","affiliation":[{"name":"Division of Nephrology Kisen Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hisadome","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kisen Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Ota","sequence":"additional","affiliation":[{"name":"Division of Nephrology Kisen Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Graduate School of Medicine Juntendo University  Tokyo 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