{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:59Z","timestamp":1747187159507,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type 1 Bartter syndrome causes hypokalaemia and metabolic alkalosis owing to mutation in the <jats:italic>SLC12A1<\/jats:italic> gene. Meanwhile, hypocalcaemia is rare in Bartter syndrome, except in type 5 Bartter syndrome. Herein, we describe two siblings with type 1 Bartter syndrome with recurrent transient severe hypocalcaemia. They each visited our hospital several times with chief complaints of numbness in the limbs, shortness of breath and tetany after stresses such as exercise or fever. Severe hypocalcaemia was also observed with a serum calcium level of approximately 6.0\u2009mg\/dL at each visit. The clinical symptoms and abnormalities in laboratory findings quickly improved with rest and intravenous treatment. In a steady state, no severe hypocalcaemia was evident, but serum intact parathyroid hormone (PTH) levels were high. In recent years, a large\u2010scale study has revealed that type 1 and type 2 Bartter syndrome have high PTH values. In addition, there are reports that these patients develop hypocalcaemia due to PTH resistance. Therefore, our patient was also in a PTH\u2010resistant state, and hypocalcaemia was thought to be exacerbated by physical stress. It is not well known that Bartter syndrome patients other than those with type 5 suffer from hypocalcaemia. And hypocalcaemia was not detected in normal examinations under steady\u2010state conditions. Therefore, in patients with type 1 and type 2 Bartter syndrome, severe hypocalcaemia may occur, but may go unnoticed. When following up these patients, the attending physician must keep in mind that such patients are in a PTH\u2010resistant state and that physical stress can cause severe hypocalcaemia.<\/jats:p>","DOI":"10.1111\/nep.14261","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T06:47:17Z","timestamp":1702018037000},"page":"164-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent transient severe hypocalcaemia in two siblings with type 1 Bartter syndrome"],"prefix":"10.1111","volume":"29","author":[{"given":"Juri","family":"Kanda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ome Municipal General Hospital  Ome Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-1221","authenticated-orcid":false,"given":"Shoichiro","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ome Municipal General Hospital  Ome Japan"},{"name":"Department of Pediatrics The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ome Municipal General Hospital  Ome Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kandai","family":"Nozu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Ariji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ome Municipal General Hospital  Ome Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ome Municipal General Hospital  Ome 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