{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:54:56Z","timestamp":1761710096833,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is evidence to suggest that M\u2010type phospholipase A2 (PLA2R) antibodies activate the mannose\u2010binding lectin (MBL) cascade, resulting in glomerular damage and proteinuria in patients with primary membranous nephropathy (PMN). Furthermore, there are few reports indicating that aberrant MBL activation is associated with endothelial dysfunction and accelerated atherosclerosis. While PMN is a common cause of adult nephrotic syndrome, and patients are at increased risk of cardiovascular disease (CVD), there is a lack of research that explores the factors that contribute to this condition. This study aims to determine the MBL levels in PMN and their relation to the clinical activity and endothelial dysfunction in PMN. The MBL levels of 22 biopsy\u2010confirmed PMN patients were assessed at baseline and after 6\u2009months of immunosuppressive therapy. In order to evaluate endothelial dysfunction in PMN patients, flow\u2010mediated vasodilation (FMD) was measured at baseline and after treatment. A total of 22 healthy controls were included in this study to measure MBL levels and FMD. A significant difference was observed between MBL levels in PMN patients and healthy controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). MBL levels decreased significantly after immunosuppressive therapy (<jats:italic>p<\/jats:italic>\u2009=\u2009.04). The baseline MBL levels and FMD levels exhibited a strong correlation (Spearman correlation coefficient [<jats:italic>\u03c1<\/jats:italic>]\u2009=\u20090.51: <jats:italic>p<\/jats:italic>\u2009=\u2009.01). In conclusion, the study signals the activation of the MBL cascade and its association with endothelial dysfunction in PMN patients.<\/jats:p>","DOI":"10.1111\/nep.14293","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:04:38Z","timestamp":1711008278000},"page":"617-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Augmented mannose\u2010binding lectin levels in primary membranous nephropathy: A pilot study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-6170","authenticated-orcid":false,"given":"Deeksha","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhjot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manphool","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupam","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ujjwal","family":"Gorsi","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritambhra","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Histopathology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-2297","authenticated-orcid":false,"given":"Harbir S.","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Nephrology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; 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