{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:07Z","timestamp":1787015887863,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Icodextrin has been widely prescribed for peritoneal dialysis (PD) patients with inadequate ultrafiltration, but icodextrin induced acute generalized exanthematous pustulosis (AGEP) has been not well recognized in clinical practice. We described a young\u2010aged female with IgA nephropathy and end stage kidney disease under continuous automated peritoneal dialysis. She developed skin erythema with exfoliation over the groin 7th day after initiation of icodextrin based PD dialysate. Initially, her scaling skin lesion with pinhead\u2010sized pustules affected the bilateral inguinal folds, and then it extended to general trunk accompanied by pruritus. She was admitted because of deterioration of skin lesion on 14th day of icodextrin exposure. She was afebrile and physical examination was notable for widespread erythematous papules with pruritus extending over her groins and trunk. Pertinent laboratory examination showed leukocytosis of 18\u2009970\u2009cells\/\u03bcL with neutrophile count of 17\u2009642\u2009cells\/\u03bcL (92.3%), and c\u2010reactive\u2010protein: 3.39\u2009mg\/dL. Skin biopsy revealed multifocal sub corneal abscess with papillary dermal edema, and upper\u2010dermal neutrophilia with perivascular accentuation, consistent with the diagnosis of AGEP. After discontinuation of PD, she underwent temporary high\u2010flux haemodialysis with treatment of steroid and antihistamine. Her dermatologic lesion resolved without any skin sequalae completely within 4\u2009days, and she underwent icodextrin\u2010free peritoneal dialysis at 17th day. This case highlighted the fact that icodextrin\u2010induced AGEP should be early recognized to avoid inappropriate management.<\/jats:p>","DOI":"10.1111\/nep.14302","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T20:14:10Z","timestamp":1712780050000},"page":"442-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Icodextrin\u2010induced acute generalized exanthematous pustulosis in a patient with peritoneal dialysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4692-0263","authenticated-orcid":false,"given":"Chun\u2010Hao","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Chou","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Tri\u2010Service General Hospital SongShan Branch, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Chien","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1071-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.36344"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04534.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08156.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.10.2656"},{"issue":"3","key":"e_1_2_6_9_1","first-page":"309","article-title":"Icodextrin cutaneous hypersensitivity: report of 3 psoriasiform cases","volume":"137","author":"Valance A","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363190-00011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686089701700117"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.511"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-018-1825-y"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.05.026"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T20:15:06Z","timestamp":1719173706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.14302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/nep.14302"],"URL":"https:\/\/doi.org\/10.1111\/nep.14302","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3098432\/v1","asserted-by":"object"}]},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"assertion":[{"value":"2023-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}