{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:46:06Z","timestamp":1747187166974,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here we present a case of complement\u2010mediated thrombotic microangiopathy (TMA) in a patient who has a background of Stage 5 chronic kidney disease secondary to Alport syndrome. We explain our approach to the diagnosis of TMA, especially the reliance on non\u2010renal manifestations of TMA and the role of kidney biopsy given there was a background of advanced kidney impairment at baseline.<\/jats:p>","DOI":"10.1111\/nep.14305","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T23:45:10Z","timestamp":1712879110000},"page":"688-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complement\u2010mediated thrombotic microangiopathy on a background of Alport syndrome: A case report"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2696-5623","authenticated-orcid":false,"given":"Craig Peter","family":"Coorey","sequence":"first","affiliation":[{"name":"Renal Unit Gosford Hospital  Gosford New South Wales Australia"},{"name":"School of Medicine Western Sydney University  Campbelltown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"de Malmanche","sequence":"additional","affiliation":[{"name":"Immunology NSW Health Pathology  Newcastle New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Feddersen","sequence":"additional","affiliation":[{"name":"Renal Unit Gosford Hospital  Gosford New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.10.014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10581014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017232"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-021-01820-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-60"},{"key":"e_1_2_6_7_1","unstructured":"Diagnosis of aHUS. 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