{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:24:34Z","timestamp":1791919474444,"version":"4.3.4"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001563","name":"Otago Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001563","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gout affects 15%\u201330% of individuals with advanced kidney disease. Allopurinol which is rapidly and extensively metabolised to an active metabolite, oxypurinol, is the most commonly prescribed urate\u2010lowering therapy. Oxypurinol is almost entirely eliminated by the kidneys (&gt;95%) and has an elimination half\u2010life of 18\u201330\u2009h in those with normal kidney function. However, oxypurinol pharmacokinetics are poorly understood in individuals with kidney failure on peritoneal dialysis. This study characterised the elimination of oxypurinol and urate in people with gout receiving peritoneal dialysis. Oxypurinol steady\u2010state oral clearance (CL\/F), elimination half\u2010life as well as kidney (CL<jats:sub>k<\/jats:sub>) and peritoneal (CL<jats:sub>pd<\/jats:sub>) clearances for oxypurinol and urate were calculated from the plasma, urine and dialysate concentration data for each individual. Our results demonstrate that oxypurinol and urate are removed by peritoneal dialysis, accounting for more than 50% of oxypurinol and urate clearances. An allopurinol dose about 50%\u201360% lower than the usual dose used for a patient with normal kidney function will provide adequate urate\u2010lowering therapy.<\/jats:p>","DOI":"10.1111\/nep.14306","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:44:10Z","timestamp":1713314650000},"page":"547-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of peritoneal dialysis on oxypurinol and urate elimination in people with gout"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2636-098X","authenticated-orcid":false,"given":"Luke C.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Medicine Dunedin School of Medicine  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Medicine Dunedin School of Medicine  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-9252","authenticated-orcid":false,"given":"Daniel F. B.","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Otago  Dunedin New Zealand"},{"name":"Sydney Pharmacy School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7765-5871","authenticated-orcid":false,"given":"Suetonia C.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Otago  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie L.","family":"Stocker","sequence":"additional","affiliation":[{"name":"Sydney Pharmacy School University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Clinical Pharmacology &amp; Toxicology St Vincent's Hospital Sydney  Sydney New South Wales Australia"},{"name":"Sydney Musculoskeletal Health Univ. of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-2871","authenticated-orcid":false,"given":"Tracey L.","family":"Putt","sequence":"additional","affiliation":[{"name":"Department of Medicine Dunedin School of Medicine  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B. W.","family":"Schollum","sequence":"additional","affiliation":[{"name":"Department of Medicine Dunedin School of Medicine  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-0956","authenticated-orcid":false,"given":"Robert J.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Medicine Dunedin School of Medicine  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14163"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007111256"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102016\u2010209707"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24180"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746080-00001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13460"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021113-170343"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T04:26:42Z","timestamp":1721881602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.14306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,16]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/nep.14306"],"URL":"https:\/\/doi.org\/10.1111\/nep.14306","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,16]]},"assertion":[{"value":"2024-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}