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The diagnosis was confirmed by bone marrow biopsy, serum and urine electrophoresis and kidney biopsy. The patient was treated with isazomil, pomalidomide and dexamethasone combination chemotherapy, followed by autologous stem cell transplantation. The patient achieved clinical remission, stable renal function and improved serum lambda free LC levels. This case highlights the challenges and advances in the diagnosis and treatment of this condition.<\/jats:p>","DOI":"10.1111\/nep.14315","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T07:03:52Z","timestamp":1715670232000},"page":"691-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple myeloma complicated with light chain cast nephropathy with focal amyloidosis: A case report"],"prefix":"10.1111","volume":"29","author":[{"given":"Yicao","family":"He","sequence":"first","affiliation":[{"name":"Division of Nephrology Affiliated Hospital of Hebei University  Baoding Hebei China"},{"name":"College of Clinical Medicine Hebei University  Baoding Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijuan","family":"Hua","sequence":"additional","affiliation":[{"name":"Division of Nephrology Affiliated Hospital of Hebei University  Baoding Hebei 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