{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:09:29Z","timestamp":1790788169324,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020258","name":"Department of Molecular Medicine, University of Pavia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020258","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the bias and accuracy of the CKD\u2010EPI\/CKiD and EKFC equations compared with the reference exogenous tracer\u2010based assessment of glomerular filtration rate (GFR) in adult and pediatric patients according to their renal transplant status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the bias and<jats:italic>P<\/jats:italic><jats:sub>30<\/jats:sub>accuracy of the CKD\u2010EPI\/CKiD and EKFC equations compared with iohexol\u2010based GFR measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the overall population (<jats:italic>n<\/jats:italic>\u2009=\u200959), the median age was 29 years (IQR, 16.0\u201346.0) and the median measured GFR was 73.9 mL\/min\/1.73m<jats:sup>2<\/jats:sup>(IQR, 57.3\u201384.6). Among non\u2010kidney transplant patients, the median was 77.7\u2009mL\/min\/1.73m<jats:sup>2<\/jats:sup>(IQR, 59.3\u201386.5), while among kidney transplant patients, it was 60.5 mL\/min\/1.73m<jats:sup>2<\/jats:sup>(IQR, 54.2\u201366.8). The bias associated with the EKFC and CKD\u2010EPI\/CKiD equations was significantly higher among kidney transplant patients than among non\u2010kidney transplant patients, with a difference between medians (Hodges\u2013Lehmann) of +10.4 mL\/min\/1.73m<jats:sup>2<\/jats:sup>(95% CI, 2.2\u201318.9;<jats:italic>p<\/jats:italic>\u2009=\u2009.02) for the EKFC and +12.1 mL\/min\/1.73m<jats:sup>2<\/jats:sup>(95% CI, 4.2\u201321.4;<jats:italic>p<\/jats:italic>\u2009=\u2009.006) for the CKD\u2010EPI\/CKiD equations. In multivariable analysis, kidney transplant status emerged as an independent factor associated with a bias of &gt;3.4 mL\/min\/1.73m<jats:sup>2<\/jats:sup>(odds ratio, 7.7; 95% CI, 1.4\u201343.3;<jats:italic>p<\/jats:italic>\u2009=\u2009.02) for the EKFC equation and a bias of &gt;13.4 mL\/min\/1.73m<jats:sup>2<\/jats:sup>(odds ratio, 15.0; 95% CI, 2.6\u201385.7;<jats:italic>p<\/jats:italic>\u2009=\u2009.002) for the CKD\u2010EPI\/CKiD equations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study, which included adolescent and young adult kidney transplant patients, both the CKD\u2010EPI\/CKiD and EKFC equations tended to overestimate the measured glomerular filtration rate, with the EKFC equation exhibiting less bias. Renal transplant status significantly influenced the degree of estimation bias.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/nep14328-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14328","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T05:13:45Z","timestamp":1716873225000},"page":"680-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The<scp>EKFC<\/scp>equation outperforms the<scp>CKD<\/scp>\u2010<scp>EPI<\/scp>and<scp>CKiD<\/scp>equations for<scp>GFR<\/scp>estimation in adolescent and young adult kidney transplant patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Chlo\u00e9","family":"Grosyeux","sequence":"first","affiliation":[{"name":"Pediatric Nephrology Department University Hospital of Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Alla","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Barb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, and Nutrition University Hospital of Nancy Nancy France"},{"name":"Reference Center for Inborn Errors of Metabolism (ORPHA67872) University Hospital of Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence Derain","family":"Dubourg","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis, Hypertension and Functional Renal Exploration, Edouard Herriot Hospital Hospices Civils de Lyon and Universit\u00e9 Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Chardon","sequence":"additional","affiliation":[{"name":"Department of Biology and Hormonology Lyon\u2010Est Hospital Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Gu\u00e9ant","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, and Nutrition University Hospital of Nancy Nancy France"},{"name":"Reference Center for Inborn Errors of Metabolism (ORPHA67872) University Hospital of Nancy Nancy France"},{"name":"INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE) Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Frimat","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Lorraine Nancy France"},{"name":"INSERM CIC\u2010EC CIE6 University of Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-4529","authenticated-orcid":false,"given":"Abderrahim","family":"Oussalah","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Division of Biochemistry, Molecular Biology, and Nutrition University Hospital of Nancy Nancy France"},{"name":"Reference Center for Inborn Errors of Metabolism (ORPHA67872) University Hospital of Nancy Nancy France"},{"name":"INSERM UMR_S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE) Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Vrillon","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Department University Hospital of Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"Kidney disease: improving global outcomes (KDIGO) CKD work group. 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