{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:06:56Z","timestamp":1790870816615,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>As one of the most serious complications of sepsis, acute kidney injury (AKI) is pathologically associated with excessive inflammation. 2,5\u2010Dihydroxyacetophenone (DHAP) is isolated from Radix rehmanniae praeparata\u00a0and exhibit potent anti\u2010inflammatory property. This research aimed at determining the role of DHAP in sepsis\u2010associated AKI (SA\u2010AKI) and the underlying mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma creatinine (Cre), blood urea nitrogen (BUN), tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u20101\u03b2 (IL\u20101\u03b2) levels of SA\u2010AKI patients were detected to evaluate their clinical characteristics. SA\u2010AKI rat models were established by using caecum ligation puncture (CLP) surgery. CLP\u2010induced rats were administered via oral gavage with 20 or 40\u2009mg DHAP after 2\u2009h of CLP surgery. Subsequently, survival rates, serum indexes, histopathological changes, inflammatory factors, renal function indexes and extracellular regulated protein kinases (ERK) and nuclear factor\u2010\u03baB (NF\u2010\u03baB) signalling pathways were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SA\u2010AKI patients exhibited markedly higher levels of plasma Cre, BUN, TNF\u2010\u03b1 and IL\u20101\u03b2 than healthy people. Compared with sham rats, CLP\u2010induced septic rats showed significantly decreased survival rate, increased serum lactate dehydrogenase activity and serum lactate level, obvious renal histopathological injury, upregulated TNF\u2010\u03b1, IL\u20101\u03b2 and TGF\u2010\u03b21 levels, elevated serum creatinine, BUN and serum cystatin C concentrations, serum neutrophil gelatinase\u2010associated lipocalin and kidney injury molecule\u20101 levels and reduced renal artery blood flow. All the above CLP\u2010induced changes in septic rats were mitigated after DHAP administration. Additionally, CLP\u2010induced elevation in phosphorylated\u2010ERK1\/2 and nuclear NF\u2010\u03baB p65 protein levels was inhibited by DHAP treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DHAP hinders SA\u2010AKI progression in rat models by inhibiting ERK and NF\u2010\u03baB signalling pathways.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/nep14335-gra-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.14335","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T06:19:04Z","timestamp":1721974744000},"page":"636-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["2,5\u2010Dihydroxyacetophenone attenuates acute kidney injury induced by intra\u2010abdominal infection in rats"],"prefix":"10.1111","volume":"29","author":[{"given":"Tao","family":"Han","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine The Affiliated Jiangning Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Affiliated Jiangning Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Affiliated Jiangning Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Affiliated Jiangning Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Affiliated Jiangning Hospital of Nanjing Medical University  Nanjing 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