{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:29:44Z","timestamp":1783067384612,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010phospholipid syndrome (APS) nephropathy is an autoimmune disease that is sometimes accompanied by systemic lupus erythematosus (SLE). Here, we report the use of rituximab to treat a case of APS nephropathy in a SLE patient with recurrent vascular thrombosis. A 52\u2010year\u2010old woman, who had been diagnosed with SLE 11\u2009years earlier, was referred to a nephrology clinic for evaluation of azotaemia and proteinuria. She had experienced spontaneous abortion at 35\u2009years of age. The patient had been diagnosed with right popliteal thrombosis at 39\u2009years of age, and with left pulmonary artery thrombosis and SLE at 41\u2009years of age. Before admission, she was undergoing anticoagulant and immunosuppressive therapies, with follow\u2010up in the rheumatology clinic. At her last outpatient clinic visit before admission, she exhibited mild bilateral lower\u2010limb pitting oedema, impaired renal function and proteinuria. Renal biopsy revealed arteriolar wall thickening, with thrombi in the capillary lumina and marked inflammatory cell infiltration in the interstitium. The patient was treated with warfarin and high\u2010dose corticosteroids. Intravenous rituximab (500\u2009mg) was also administered twice at a 4\u2010week interval. Her renal function did not worsen any further, and her proteinuria decreased. Here we report the successful use of rituximab to treat APS nephropathy in a patient with SLE, who had progressive renal insufficiency.<\/jats:p>","DOI":"10.1111\/nep.14375","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T09:32:21Z","timestamp":1722418341000},"page":"758-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful treatment with rituximab in anti\u2010phospholipid syndrome nephropathy associated with systemic lupus erythematosus: A case report and literature review"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-3665","authenticated-orcid":false,"given":"Ji\u2010Young","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eon Jeong","family":"Nam","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010hoon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kyungpook National University  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-0752","authenticated-orcid":false,"given":"Yong\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kyungpook National University  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Hoon","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, School of Medicine Kyungpook National University  Daegu 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