{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:05:53Z","timestamp":1791533153636,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n In India, 85% of organ donations are from living donors and 15% are from deceased donors. One\u2010third of living donors were rejected because of ABO or HLA incompatibility. Kidney exchange transplantation (KET) is a cost\u2010effective and legal strategy to increase living donor kidney transplantation (LDKT) by 25%\u201335%.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We report our experience with 539 KET cases and the evolution of a single\u2010centre program to increase the use of LDKT.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Between January 2000 and 13 March, 2024, 1382 deceased donor kidney transplantations and 5346 LDKT were performed at our centre, including 10% (\n n<\/jats:italic>\n \u2009=\u2009539) from KET. Of the 539 KET, 80.9% (\n n<\/jats:italic>\n \u2009=\u2009436) were ABO incompatible pairs, 11.1% (\n n<\/jats:italic>\n \u2009=\u200960) were compatible pairs, and 8% (n\u2009=\u200943) were sensitized pairs. There were 75% 2\u2010way (\n n<\/jats:italic>\n \u2009=\u20092\u2009\u00d7\u2009202\u2009=\u2009404), 16.2% 3\u2010way (\n n<\/jats:italic>\n \u2009=\u20093\u2009\u00d7\u200929\u2009=\u200987), 3% 4\u2010way (\n n<\/jats:italic>\n \u2009=\u20094\u2009\u00d7\u20094\u2009=\u200916), 1.8% 5\u2010way (\n n<\/jats:italic>\n \u2009=\u20095\u2009\u00d7\u20092\u2009=\u200910), 2.2% 6\u2010way (\n n<\/jats:italic>\n \u2009=\u20096\u2009\u00d7\u20092\u2009=\u200912), and 1.8% 10\u2010way KET (\n n<\/jats:italic>\n \u2009=\u200910\u2009\u00d7\u20091\u2009=\u200910). Of the recipients 81.2% (\n n<\/jats:italic>\n \u2009=\u2009438) were male and 18.8% (\n n<\/jats:italic>\n \u2009=\u2009101) were female, while of the donors, 78.5% (\n n<\/jats:italic>\n \u2009=\u2009423) were female and 21.5% (\n n<\/jats:italic>\n \u2009=\u2009116) were male. All donors were near relatives; wives (54%,\n n<\/jats:italic>\n \u2009=\u2009291) and mothers (20%,\n n<\/jats:italic>\n \u2009=\u2009108) were the most common donors. At a median follow\u2010up of 8.2\u2009years, patient survival, death censored graft survival, acute rejection, and median serum creatinine levels of functioning grafts were 81.63% (\n n<\/jats:italic>\n \u2009=\u2009440), 91% (\n n<\/jats:italic>\n \u2009=\u2009494), 9.8% (\n n<\/jats:italic>\n \u2009=\u200953) and 1.3\u2009mg\/dL respectively. We credited the success to maintaining a registry of incompatible pairs, high\u2010volume LDKT programs, non\u2010anonymous allocation and teamwork.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This is the largest single\u2010centre KET program in Asia. We report the challenges and solutions to replicate our success in other KET programs.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nep.14380","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T19:58:52Z","timestamp":1725825532000},"page":"917-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of single centre kidney\u2010exchange transplantation to increase living donor pool in\n India<\/scp>\n : A cohort study involving non\u2010anonymous allocation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-2854","authenticated-orcid":false,"given":"Vivek B.","family":"Kute","sequence":"first","affiliation":[{"name":"Department of Nephrology and Clinical Transplantation Institute of Kidney Diseases and Research Center, Dr HL Trivedi Institute of 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