{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:08:22Z","timestamp":1788750502382,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Kidney transplant (KT) requires long\u2010term glucocorticoid (GC) treatment against acute and\/or chronic rejection. Glucocorticoid\u2010induced osteoporosis (GIOP) is one of the major concerns in kidney transplant recipients (KTRs). Therefore, it is essential to accumulate GIOP data from paediatric KTRs to aid in their healthy growth. A serial observational study of bone strength was carried out in an 8\u2010year\u2010old girl with bilateral hypoplastic kidney who underwent ABO\u2010compatible living\u2010donor KT and GC treatment over 2\u2009years. Bone strength was evaluated by bone mineral density (BMD) and serum bone turnover markers (BTMs), including serum alkaline phosphatase (S\u2010ALP), serum tartrate\u2010resistant acid phosphatase 5b (S\u2010TRACP\u20105b), and serum undercarboxylated osteocalcin (S\u2010ucOC). All the levels of BTMs and BMD from 1\u2009M to 4\u2009M remained lower than the levels at 0\u2009months (0\u2009M: baseline). After gradual reduction of GC dose (4\u2009M\u201324\u2009M), S\u2010ALP levels increased from baseline and S\u2010TRACP\u20105b levels remained lower than the baseline level, but BMD recovered to baseline and increased. The S\u2010ucOC levels did not increase from baseline. The patient's height growth velocity SDS was +3.99 for 23\u2009months, and no fracture occurred during this observation period. A consistent, predominantly formative state of bone, which maintained higher S\u2010ALP levels and lower S\u2010TRACP\u20105b levels compared to baseline, could contribute to increased BMD. In addition, no increase in S\u2010ucOC levels from baseline could be associated with no deterioration of bone strength. This case suggests that measurement of BMD and, S\u2010ALP, TRACP\u20105b and ucOC could be useful for evaluating the trend on bone strength in a paediatric KTR.<\/jats:p>","DOI":"10.1111\/nep.14382","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T05:20:06Z","timestamp":1727155206000},"page":"955-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Trends of bone mineral density and bone quality in a paediatric kidney transplant recipient: A case report"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-6797","authenticated-orcid":false,"given":"Jun","family":"Aoyagi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-6201","authenticated-orcid":false,"given":"Takahiro","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takane","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Betsui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Maru","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Tajima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90138-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(01)00226-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011050480"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.08.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.25.71"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-020-04499-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.5.1497"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2588000"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1012926"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-2-382"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13832"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01623351"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afos.2016.12.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13253"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.3.3805"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2954-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.03.008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.040912"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090407"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.14382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:45:48Z","timestamp":1788749148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.14382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/nep.14382"],"URL":"https:\/\/doi.org\/10.1111\/nep.14382","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]},"assertion":[{"value":"2024-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}