{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:07:47Z","timestamp":1788746867923,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007658","name":"Baxter Healthcare Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exploration of the incidence and outcomes of Acute Kidney Injury (AKI) broadly, and sepsis associated AKI specifically, in Aboriginal and Torres Strait Islander (First Nations) people has been limited. We compared a nested cohort of First Nations people drawn from a multinational randomised controlled trial of hydrocortisone in septic shock, to a cohort matched for age, sex and severity of illness. Acute Kidney Injury was defined using the Kidney Disease Improving Global Outcomes (KDIGO) criteria, as well as incident use of kidney replacement therapy (KRT). Major Adverse Kidney Events (MAKE) were described as the composite of death, new dialysis requirement or persisting kidney dysfunction at hospital discharge. A cohort of 57 Aboriginal and\/or Torres Strait Islander patients with septic shock was identified. 91.2% (52) of the First Nations cohort met KDIGO criteria for Stage 1 AKI or greater and 63% (36) met Stage 3 criteria. 59.6% (34) of the First Nations required dialysis as compared to 45.6% (26) in the matched cohort. 60.7% (34) of First Nations participants met criteria for MAKE at hospital discharge. The proportions requiring dialysis at 6, 12 and 24\u2009months were 8.3%, 9.1% and 6.9% respectively. The incidences of AKI and MAKE reported in this First Nations cohort are substantially higher than in previously published cohorts of patients with sepsis, even those that use sensitive definitions of AKI. Measures to promote better management of infectious diseases in First Nations communities are required.<\/jats:p>","DOI":"10.1111\/nep.14405","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T21:04:19Z","timestamp":1728421459000},"page":"1000-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sepsis associated acute kidney injury is common among Aboriginal and Torres Strait Islanders with septic shock and has poor outcomes: A nested cohort study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3530-785X","authenticated-orcid":false,"given":"L. H.","family":"Donaldson","sequence":"first","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine, UNSW Sydney  Sydney New South Wales Australia"},{"name":"Malcolm Fisher Department of Intensive Care Medicine Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. E.","family":"Hammond","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine, UNSW Sydney  Sydney New South Wales Australia"},{"name":"Malcolm Fisher Department of Intensive Care Medicine Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"Smyth","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Darwin Hospital  Northern Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Darwin Hospital  Northern Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research Charles Darwin University  Casuarina Northern Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bompoint","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Coombes","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bennett\u2010Brook","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine, UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Critical Care The University of Melbourne  Melbourne Victoria Australia"},{"name":"Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Data Analytics Research &amp; Evaluation Centre The University of Melbourne and Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Myburgh","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine, UNSW Sydney  Sydney New South Wales Australia"},{"name":"Department of Intensive Care Medicine St. George Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health Faculty of Medicine, UNSW Sydney  Sydney New South Wales Australia"},{"name":"Intensive Care Unit Princess Alexandra and Wesley Hospitals  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1441-2772(23)00528-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2011.tb03088.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50649"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Twelve\u2010month mortality outcomes for indigenous and non\u2010indigenous people admitted to intensive care units in Australia: a registry\u2010based data linkage study","volume":"218","author":"Secombe PJ","year":"2022","journal-title":"Med J Aust"},{"key":"e_1_2_7_6_1","first-page":"120","volume-title":"A Modern Epidemic: Expert Perspectives on Obesity and Diabetes","author":"Cass A","year":"2012"},{"key":"e_1_2_7_7_1","volume-title":"Profiles of Aboriginal and Torres Strait Islander people with kidney disease","author":"Australian Institute of Health and Welfare","year":"2020"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50061"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2019.10.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH18230"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50232"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006284"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00683-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.01.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-01974-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.51893\/2022.1.OA3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705835"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363725"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05837-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12133"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-022-01040-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268817001716"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.14405","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.14405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:24:23Z","timestamp":1788744263000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.14405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/nep.14405"],"URL":"https:\/\/doi.org\/10.1111\/nep.14405","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]},"assertion":[{"value":"2024-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}